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PMID: 11462049 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection.

Journal of virology ·Vol. 75 ·No. 16 ·2001-08-00 ·Pages 7744-8

Flaño E, Woodland DL, Blackman MA, Doherty PC

Abstract

Major histocompatibility complex class II-mediated antigen presentation after intranasal infection with murine gammaherpesvirus 68 differs in mediastinal lymph nodes and spleen. Evidence that virus-specific CD4(+) T cells were being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp150(67-83) and ORF11(168-180) peptides were maintained as a fairly stable proportion of the total response.

MeSH Terms
Animals Antigens, Viral/immunology CD4-Positive T-Lymphocytes/immunology Gammaherpesvirinae Herpesviridae Infections/immunology Immunity, Cellular Mice Time Factors
Chemicals
Antigens, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Flaño E
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Woodland D L
Blackman M A
Doherty P C
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.75.16.7744-7748.2001
Published
2001-08-00
Pages
7744-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC115012
Subset
IM
Grants
NCI NIH HHS · CA21765 · United States
NIAID NIH HHS · R37 AI029579 · United States
NCI NIH HHS · P30 CA021765 · United States
NIAID NIH HHS · AI29579 · United States
NIAID NIH HHS · AI38359 · United States
External Links
PubMed source DOI: 10.1128/JVI.75.16.7744-7748.2001 PMC Full Text View journal details
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