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PMID: 11516340 Published · ppublish English Journal Article Review

Histone variants: are they functionally heterogeneous?

Genome biology ·Vol. 2 ·No. 7 ·2001-00-00 ·Pages REVIEWS0006

Brown DT

Abstract

In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute to a distinct or unique nucleosomal architecture, this heterogeneity can be exploited to regulate a wide range of nuclear functions, and evidence is accumulating that histone variants do indeed have distinct functions.

MeSH Terms
Animals Chromatin/genetics Gene Expression Regulation Genetic Variation Histones/genetics,physiology Humans Multigene Family/genetics,physiology Nucleosomes/genetics Transcription, Genetic
Chemicals
Chromatin Histones Nucleosomes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brown D T
Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA. [email protected]
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36 references, click to expand
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
DOI
10.1186/gb-2001-2-7-reviews0006
Email
[email protected]
Published
2001-00-00
Epub
2001-00-05
Pages
REVIEWS0006
Language
English
Region
England
NLM ID
100960660
PMCID
PMC139417
Subset
IM
External Links
PubMed source DOI: 10.1186/gb-2001-2-7-reviews0006 PMC Full Text View journal details
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