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PMID: 11581294 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.

The Journal of clinical investigation ·Vol. 108 ·No. 7 ·2001-10-00 ·Pages 949-55

Schmidt AM, Yan SD, Yan SF, Stern DM

Abstract

暂无摘要

MeSH Terms
Amyloidosis/immunology,metabolism Animals Diabetes Mellitus, Experimental/immunology,metabolism Glycation End Products, Advanced/immunology,metabolism HMGB1 Protein/metabolism Humans Membrane Proteins/immunology,metabolism Neoplasms/immunology Receptor for Advanced Glycation End Products Receptors, Immunologic/immunology,metabolism
Chemicals
Glycation End Products, Advanced HMGB1 Protein Membrane Proteins Receptor for Advanced Glycation End Products Receptors, Immunologic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schmidt A M
Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
Yan S D
Yan S F
Stern D M
References (40)
40 references, click to expand
  1. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression.
    J Biol Chem. 1999 Oct 29;274(44):31740-9 PMID: 10531386
  2. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity.
    Semin Immunol. 1998 Oct;10(5):363-72 PMID: 9799711
  3. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice.
    J Clin Invest. 2000 Apr;105(8):1117-24 PMID: 10772656
  4. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases.
    Nature. 2000 May 18;405(6784):354-60 PMID: 10830965
  5. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
    Nat Med. 2000 Jun;6(6):643-51 PMID: 10835680
  6. Innate immunity.
    N Engl J Med. 2000 Aug 3;343(5):338-44 PMID: 10922424
  7. The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells.
    J Biol Chem. 2000 Aug 18;275(33):25781-90 PMID: 10829018
  8. Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.
    Am J Pathol. 2001 Aug;159(2):513-25 PMID: 11485910
  9. Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale.
    J Clin Invest. 2001 Sep;108(5):649-54 PMID: 11544267
  10. Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways.
    J Neurosci. 2001 Oct 1;21(19):7576-86 PMID: 11567048
  11. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.
    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9178-82 PMID: 2251261
  12. Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells.
    J Biol Chem. 1998 Nov 20;273(47):30870-8 PMID: 9812979
  13. Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells.
    Diabetologia. 1998 Dec;41(12):1435-41 PMID: 9867210
  14. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways.
    J Biol Chem. 1999 Jul 9;274(28):19919-24 PMID: 10391939
  15. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides.
    Cell. 1999 Jun 25;97(7):889-901 PMID: 10399917
  16. Recognition and plasma clearance of endotoxin by scavenger receptors.
    Nature. 1991 Jul 25;352(6333):342-4 PMID: 1852209
  17. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.
    J Biol Chem. 1992 Jul 25;267(21):14987-97 PMID: 1321822
  18. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
    J Biol Chem. 1992 Jul 25;267(21):14998-5004 PMID: 1378843
  19. Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.
    J Clin Invest. 1993 May;91(5):2155-68 PMID: 8387541
  20. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.
    J Biol Chem. 1994 Apr 1;269(13):9889-97 PMID: 8144582
  21. The B7 and CD28 receptor families.
    Immunol Today. 1994 Jul;15(7):321-31 PMID: 7522010
  22. Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.
    Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8807-11 PMID: 8090728
  23. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).
    Annu Rev Biochem. 1994;63:601-37 PMID: 7979249
  24. Advanced protein glycosylation in diabetes and aging.
    Annu Rev Med. 1995;46:223-34 PMID: 7598459
  25. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.
    J Clin Invest. 1995 Sep;96(3):1395-403 PMID: 7544803
  26. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system.
    J Biol Chem. 1995 Oct 27;270(43):25752-61 PMID: 7592757
  27. The dark side of glucose.
    Nat Med. 1995 Oct;1(10):1002-4 PMID: 7489352
  28. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.
    J Clin Invest. 1996 Jan 1;97(1):238-43 PMID: 8550841
  29. The S100 family of EF-hand calcium-binding proteins: functions and pathology.
    Trends Biochem Sci. 1996 Apr;21(4):134-40 PMID: 8701470
  30. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
    Nature. 1996 Aug 22;382(6593):685-91 PMID: 8751438
  31. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.
    J Clin Invest. 1996 Sep 1;98(5):1088-94 PMID: 8787669
  32. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.
    Neuron. 1996 Sep;17(3):553-65 PMID: 8816718
  33. Advanced glycation end products-driven angiogenesis in vitro. Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor.
    J Biol Chem. 1997 Mar 28;272(13):8723-30 PMID: 9079706
  34. Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products.
    J Biol Chem. 1997 Jun 27;272(26):16498-506 PMID: 9195959
  35. Advanced glycation end product (AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE.
    Circulation. 1997 Oct 7;96(7):2262-71 PMID: 9337199
  36. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.
    J Clin Invest. 1997 Nov 1;100(9):2333-40 PMID: 9410912
  37. A family of human receptors structurally related to Drosophila Toll.
    Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93 PMID: 9435236
  38. Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts.
    Nat Med. 1998 Sep;4(9):1025-31 PMID: 9734395
  39. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
    J Biol Chem. 1998 Nov 6;273(45):29719-26 PMID: 9792685
  40. beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
    J Biol Chem. 2000 Feb 25;275(8):5626-32 PMID: 10681545
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI14002
Published
2001-10-00
Pages
949-55
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC200958
Subset
IM
Grants
NHLBI NIH HHS · HL-60901 · United States
NIA NIH HHS · AG-17490 · United States
NIA NIH HHS · P01 AG017490 · United States
NHLBI NIH HHS · P01 HL060901 · United States
NIA NIH HHS · AG-16223 · United States
External Links
PubMed source DOI: 10.1172/JCI14002 PMC Full Text View journal details
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