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PMID: 11598100 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins.

Infection and immunity ·Vol. 69 ·No. 11 ·2001-11-00 ·Pages 7187-9

Collin M, Olsén A

Abstract

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.

MeSH Terms
Antibodies, Bacterial/metabolism Bacterial Proteins/metabolism Cysteine Endopeptidases/metabolism Glycoside Hydrolases/metabolism Humans Immunoglobulin A/metabolism Immunoglobulin D/metabolism Immunoglobulin E/metabolism Immunoglobulin G/metabolism Immunoglobulin M/metabolism Immunoglobulins/metabolism Streptococcus pyogenes/enzymology Substrate Specificity
Chemicals
Antibodies, Bacterial Bacterial Proteins Immunoglobulin A Immunoglobulin D Immunoglobulin G Immunoglobulin M Immunoglobulins Immunoglobulin E Glycoside Hydrolases NDOS protein, Streptococcus pyogenes Cysteine Endopeptidases streptopain
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Collin M
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden. [email protected]
Olsén A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.69.11.7187-7189.2001
Email
[email protected]
Published
2001-11-00
Pages
7187-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC100124
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.69.11.7187-7189.2001 PMC Full Text View journal details
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