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PMID: 11667979 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Role of gammadelta T cells in protecting normal airway function.

Respiratory research ·Vol. 1 ·No. 3 ·2000-00-00 ·Pages 151-8

Born WK, Lahn M, Takeda K, Kanehiro A, O'Brien RL, Gelfand EW

Abstract

Since their discovery 15 years ago, the role of gammadelta T cells has remained somewhat elusive. Responses of gammadelta T cells have been found in numerous infectious and non-infectious diseases. New evidence points to gammadelta T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of gammadelta T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

MeSH Terms
Animals Immunity Receptors, Antigen, T-Cell, gamma-delta/metabolism Respiratory System/immunology T-Lymphocyte Subsets/physiology T-Lymphocytes/physiology
Chemicals
Receptors, Antigen, T-Cell, gamma-delta
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Born W K
National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Lahn M
Takeda K
Kanehiro A
O'Brien R L
Gelfand E W
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Article Info
Journal
Respiratory research
Abbr.
Respir Res
ISSN
1465-9921
DOI
10.1186/rr26
Published
2000-00-00
Epub
2000-00-07
Pages
151-8
Language
English
Region
England
NLM ID
101090633
PMCID
PMC59553
Subset
IM
Grants
NIAID NIH HHS · AI-01291 · United States
NHLBI NIH HHS · P01 HL036577 · United States
NIAID NIH HHS · R01 AI040611 · United States
NIAID NIH HHS · AI-40611 · United States
NHLBI NIH HHS · HL-36577 · United States
External Links
PubMed source DOI: 10.1186/rr26 PMC Full Text
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