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PMID: 8228828 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The presence of an endogenous murine leukemia virus sequence correlates with the peripheral expansion of gamma delta T cells bearing the BALB invariant delta (BID) T cell receptor delta.

The Journal of experimental medicine ·Vol. 178 ·No. 5 ·1993-11-01 ·Pages 1819-24

Sim GK, Augustin A

Abstract

gamma delta T cells participate in immune responses during viral, bacterial, and parasitic infections. However, it is not clear whether they recognize antigens produced by pathogens, or are actually reactive to self-ligands generated during the course of infection. In this paper, we report that the presence of the self-ligand that selectively expands a subset of gamma delta T cells correlates with the presence of an endogenous murine leukemia virus (MuLV) in inbred strains of mice. The implications of this observation for gamma delta T cell specificity and function is discussed.

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA/chemistry,isolation & purification DNA Primers Gene Expression Leukemia Virus, Murine/isolation & purification Mice Mice, Hairless Mice, Inbred BALB C/immunology Mice, Inbred Strains/immunology Molecular Sequence Data Polymerase Chain Reaction Receptors, Antigen, T-Cell, gamma-delta/biosynthesis Species Specificity T-Lymphocytes/drug effects,immunology
Chemicals
DNA Primers Receptors, Antigen, T-Cell, gamma-delta DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sim G K
Basel Institute for Immunology, Switzerland.
Augustin A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.178.5.1819
Published
1993-11-01
Pages
1819-24
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2191222
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.178.5.1819 PMC Full Text View journal details
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