Home LiteratureArticle Details
PMID: 11686897 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease.

Respiratory research ·Vol. 2 ·No. 5 ·2001-00-00 ·Pages 280-5

Klings ES, Farber HW

Abstract

Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) and/or platelets, and the vascular endothelium. One potential mechanism of vascular damage in ACS is by generation of oxygen-related molecules, such as superoxide (O2-), hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and the hydroxyl (*OH) radical. The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process.

MeSH Terms
Anemia, Sickle Cell/blood,complications,physiopathology Animals Antioxidants/metabolism Erythrocytes/metabolism Free Radicals/blood Humans Leukocytes/metabolism Oxidants/blood Thorax/physiology
Chemicals
Antioxidants Free Radicals Oxidants
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Klings E S
The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA. [email protected]
Farber H W
References (61)
61 references, click to expand
  1. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group.
    N Engl J Med. 2000 Jun 22;342(25):1855-65 PMID: 10861320
  2. Relationship of plasma alpha tocopherol to index of clinical severity in individuals with sickle cell anemia.
    Am J Hematol. 1992 Dec;41(4):227-31 PMID: 1288284
  3. Reperfusion injury pathophysiology in sickle transgenic mice.
    Blood. 2000 Jul 1;96(1):314-20 PMID: 10891467
  4. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice.
    J Clin Invest. 2000 Aug;106(3):411-20 PMID: 10930444
  5. Status of myocardial antioxidants in ischemia-reperfusion injury.
    Cardiovasc Res. 2000 Aug 18;47(3):446-56 PMID: 10963718
  6. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome.
    J Pediatr Hematol Oncol. 2000 Nov-Dec;22(6):515-20 PMID: 11132219
  7. An unusual pattern of neutrophil kinetics in sickle cell anemia.
    Blood. 1973 Jan;41(1):59-65 PMID: 4682080
  8. Activated oxygen and haemolysis.
    Br J Haematol. 1975 Jul;30(3):259-64 PMID: 172110
  9. Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia: evidence for increased susceptibility to lipid peroxidation in vivo.
    J Lab Clin Med. 1979 Oct;94(4):542-8 PMID: 479666
  10. A decrease in irreversibly sickled erythrocytes in sicle cell anemia patients given vitamin E.
    Am J Clin Nutr. 1980 May;33(5):968-71 PMID: 6154411
  11. Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes.
    Br J Haematol. 1980 Jan;44(1):87-92 PMID: 7378296
  12. Biology of disease: free radicals and tissue injury.
    Lab Invest. 1982 Nov;47(5):412-26 PMID: 6290784
  13. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.
    Arch Biochem Biophys. 1993 Feb 1;300(2):535-43 PMID: 8434935
  14. Inhibition of endothelium-dependent vasorelaxation by sickle erythrocytes.
    Am Heart J. 1993 Aug;126(2):338-46 PMID: 8338004
  15. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.
    J Clin Invest. 1993 Oct;92(4):1866-74 PMID: 7691889
  16. Increased in vivo activation of neutrophils and complement in sickle cell disease.
    Am J Trop Med Hyg. 1993 Dec;49(6):799-803 PMID: 8279646
  17. Mortality in sickle cell disease. Life expectancy and risk factors for early death.
    N Engl J Med. 1994 Jun 9;330(23):1639-44 PMID: 7993409
  18. Sickle reticulocytes adhere to VCAM-1.
    Blood. 1995 Jan 1;85(1):268-74 PMID: 7528569
  19. Plasma levels of retinol, ascorbic acid and alpha-tocopherol in sickle cell anaemia.
    Cent Afr J Med. 1995 Feb;41(2):48-50 PMID: 7788666
  20. Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture.
    J Clin Invest. 1995 Aug;96(2):1145-51 PMID: 7635951
  21. Kinetic analysis of the fate of nitric oxide synthesized by macrophages in vitro.
    J Biol Chem. 1995 Dec 8;270(49):29350-5 PMID: 7493969
  22. The metabolites of nitric oxide in sickle-cell disease.
    Br J Haematol. 1995 Dec;91(4):834-7 PMID: 8547126
  23. The release of nitric oxide and superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anaemia.
    Br J Haematol. 1996 May;93(2):333-40 PMID: 8639425
  24. Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst.
    Blood. 1996 May 15;87(10):4440-7 PMID: 8639806
  25. Nitric oxide regulation of tissue free radical injury.
    Chem Res Toxicol. 1996 Jul-Aug;9(5):809-20 PMID: 8828915
  26. Antioxidant status and susceptibility of sickle erythrocytes to oxidative and osmotic stress.
    Free Radic Res. 1996 Aug;25(2):133-9 PMID: 8885331
  27. Nitric oxide metabolite levels in acute vaso-occlusive sickle-cell crisis.
    Acad Emerg Med. 1996 Dec;3(12):1098-103 PMID: 8959162
  28. Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition.
    Blood. 1997 Jun 15;89(12):4591-9 PMID: 9192784
  29. Endothelin-1 production during the acute chest syndrome in sickle cell disease.
    Am J Respir Crit Care Med. 1997 Jul;156(1):280-5 PMID: 9230761
  30. Homocysteine in sickle cell disease: relationship to stroke.
    Am J Med. 1997 Sep;103(3):192-6 PMID: 9316551
  31. Nitric oxide synthases: which, where, how, and why?
    J Clin Invest. 1997 Nov 1;100(9):2146-52 PMID: 9410890
  32. Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64.
    Blood. 1998 Jan 1;91(1):266-74 PMID: 9414294
  33. Biosynthesis and action of nitric oxide in mammalian cells.
    Trends Biochem Sci. 1997 Dec;22(12):477-81 PMID: 9433128
  34. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes.
    Blood. 1998 Nov 15;92(10):3924-35 PMID: 9808586
  35. Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
    Kidney Int. 1998 Nov;54(5):1520-8 PMID: 9844128
  36. Elevated IL-8 levels during sickle cell crisis.
    Eur J Haematol. 1998 Nov;61(5):302-5 PMID: 9855244
  37. Transgenic HbS mouse neutrophils in increased susceptibility to acute lung injury: implications for sickle acute chest syndrome.
    Chest. 1999 Jul;116(1 Suppl):92S PMID: 10424612
  38. Sickle cell acute chest syndrome: pathogenesis and rationale for treatment.
    Blood. 1999 Sep 1;94(5):1555-60 PMID: 10477680
  39. Neutrophil activation in sickle cell disease.
    J Leukoc Biol. 1999 Sep;66(3):411-5 PMID: 10496310
  40. Endothelial cell nitric oxide production in acute chest syndrome.
    Am J Physiol. 1999 Oct;277(4 Pt 2):H1579-92 PMID: 10516198
  41. Oxidative stress as a regulator of gene expression in the vasculature.
    Circ Res. 1999 Oct 15;85(8):753-66 PMID: 10521248
  42. GLUTATHIONE PEROXIDASE: THE PRIMARY AGENT FOR THE ELIMINATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES.
    Biochemistry. 1963 Nov-Dec;2:1420-8 PMID: 14093920
  43. Spontaneous oxygen radical generation by sickle erythrocytes.
    J Clin Invest. 1982 Dec;70(6):1253-9 PMID: 6294138
  44. A novel phospholipid in irreversibly sickled cells: evidence for in vivo peroxidative membrane damage in sickle cell disease.
    Blood. 1984 Feb;63(2):362-7 PMID: 6692040
  45. Ascorbic acid in sickle cell disease: results of a pilot therapeutic trial.
    East Afr Med J. 1983 Oct;60(10):683-7 PMID: 6671426
  46. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor.
    Nature. 1986 Apr 3-9;320(6061):454-6 PMID: 3007998
  47. Sickle cell membranes and oxidative damage.
    Biochem J. 1986 Jul 1;237(1):265-9 PMID: 3800879
  48. Altered amount and activity of superoxide dismutase in sickle cell anemia.
    FASEB J. 1988 Mar 1;2(3):237-43 PMID: 3350236
  49. Oxidative hemoglobin denaturation and RBC destruction: the effect of heme on red cell membranes.
    Semin Hematol. 1989 Apr;26(2):128-35 PMID: 2658088
  50. Endothelial cell killing by neutrophils. Synergistic interaction of oxygen products and proteases.
    Am J Pathol. 1989 Sep;135(3):435-8 PMID: 2675621
  51. Selected indices of micronutrient status in adult patients with sickle cell anemia (SCA).
    Am J Hematol. 1989 Nov;32(3):161-6 PMID: 2816908
  52. Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease.
    Eur J Clin Nutr. 1989 Sep;43(9):609-14 PMID: 2606092
  53. Low plasma prealbumin and carotenoid levels in sickle cell disease patients.
    Am J Med Sci. 1990 Jan;299(1):13-5 PMID: 2296992
  54. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
    Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620-4 PMID: 2154753
  55. Serum vitamin E and the sickling status in children with sickle cell anaemia.
    East Afr Med J. 1990 Oct;67(10):720-5 PMID: 2282895
  56. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide.
    Arch Biochem Biophys. 1991 Aug 1;288(2):481-7 PMID: 1654835
  57. Endogenous nitric oxide: physiology, pathology and clinical relevance.
    Eur J Clin Invest. 1991 Aug;21(4):361-74 PMID: 1718757
  58. Adaptive responses of the endothelium to stress.
    J Surg Res. 2000 Mar;89(1):85-119 PMID: 10720457
  59. Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis.
    Am J Hematol. 2000 May;64(1):15-9 PMID: 10815782
  60. Biochemistry of nitric oxide and its redox-activated forms.
    Science. 1992 Dec 18;258(5090):1898-902 PMID: 1281928
  61. Reactive species in sickle cell disease.
    Ann N Y Acad Sci. 2000;899:375-91 PMID: 10863554
Article Info
Journal
Respiratory research
Abbr.
Respir Res
ISSN
1465-9921
DOI
10.1186/rr70
Email
[email protected]
Published
2001-00-00
Epub
2001-00-13
Pages
280-5
Language
English
Region
England
NLM ID
101090633
PMCID
PMC59517
Subset
IM
External Links
PubMed source DOI: 10.1186/rr70 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2