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PMID: 11751111 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.

Antimicrobial agents and chemotherapy ·Vol. 46 ·No. 1 ·2002-01-00 ·Pages 55-61

Bacchi CJ, Weiss LM, Lane S, Frydman B, Valasinas A, Reddy V, Sun JS, Marton LJ, Khan IA, Moretto M, Yarlett N, Wittner M

Abstract

Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

MeSH Terms
AIDS-Related Opportunistic Infections/drug therapy Animals Disease Models, Animal Encephalitozoon cuniculi/drug effects Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Microsporidiosis/drug therapy Parasitic Sensitivity Tests Polyamines/adverse effects,chemistry,therapeutic use Treatment Outcome
Chemicals
Polyamines
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Bacchi Cyrus J
Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038-1598, USA. [email protected]
Weiss Louis M
Lane Schenella
Frydman Benjamin
Valasinas Aldonia
Reddy Venodhar
Sun Jerry S
Marton Laurence J
Khan Imitiaz A
Moretto Magali
Yarlett Nigel
Wittner Murray
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
Published
2002-01-00
Pages
55-61
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC127003
Subset
IM
Grants
NIAID NIH HHS · AI43693 · United States
NIAID NIH HHS · R01 AI041398 · United States
NIAID NIH HHS · R01 AI043693 · United States
NIAID NIH HHS · AI 43094 · United States
NIAID NIH HHS · R01 AI031788 · United States
NIAID NIH HHS · R01 AI031788-11 · United States
NIAID NIH HHS · AI 41398 · United States
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