Home LiteratureArticle Details
PMID: 11751844 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

High frequency of mutator strains among human uropathogenic Escherichia coli isolates.

Journal of bacteriology ·Vol. 184 ·No. 2 ·2002-01-00 ·Pages 605-9

Denamur E, Bonacorsi S, Giraud A, Duriez P, Hilali F, Amorin C, Bingen E, Andremont A, Picard B, Taddei F, Matic I

Abstract

By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains.

MeSH Terms
Anti-Bacterial Agents/pharmacology Drug Resistance, Bacterial Dysentery, Bacillary/microbiology Escherichia coli/drug effects,genetics,isolation & purification,pathogenicity Escherichia coli Infections/microbiology Genetic Variation Humans Mutation Shigella/drug effects,genetics,isolation & purification,pathogenicity Urinary Tract Infections/microbiology
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Denamur Erick
INSERM U 458, Hôpital Robert, Debré, Paris, France.
Bonacorsi Stéphane
Giraud Antoine
Duriez Patrick
Hilali Farida
Amorin Christine
Bingen Edouard
Andremont Antoine
Picard Bertrand
Taddei François
Matic Ivan
References (22)
22 references, click to expand
  1. The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitness.
    Genetics. 2000 Mar;154(3):959-70 PMID: 10757746
  2. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance.
    Science. 2000 Feb 25;287(5457):1479-82 PMID: 10688795
  3. Prevalence of virulence genes and clonality in Escherichia coli strains that cause bacteremia in cancer patients.
    Infect Immun. 2000 Jul;68(7):3983-9 PMID: 10858212
  4. Evolutionary implications of the frequent horizontal transfer of mismatch repair genes.
    Cell. 2000 Nov 22;103(5):711-21 PMID: 11114328
  5. Mutator natural Escherichia coli isolates have an unusual virulence phenotype.
    Infect Immun. 2001 Jan;69(1):9-14 PMID: 11119483
  6. Biofilm formation in a hydrodynamic environment by novel fimh variants and ramifications for virulence.
    Infect Immun. 2001 Mar;69(3):1322-8 PMID: 11179294
  7. Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut.
    Science. 2001 Mar 30;291(5513):2606-8 PMID: 11283373
  8. Mismatch repair and the regulation of phase variation in Neisseria meningitidis.
    Mol Microbiol. 2001 May;40(3):645-55 PMID: 11359570
  9. Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations.
    Microbiology. 2001 Jun;147(Pt 6):1671-6 PMID: 11390698
  10. Potential of Escherichia coli isolated from nature to propagate cloning vectors.
    Nature. 1980 Jan 3;283(5742):104-6 PMID: 6444244
  11. Standard reference strains of Escherichia coli from natural populations.
    J Bacteriol. 1984 Feb;157(2):690-3 PMID: 6363394
  12. cAMP-dependent SOS induction and mutagenesis in resting bacterial populations.
    Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11736-40 PMID: 8524839
  13. High mutation frequencies among Escherichia coli and Salmonella pathogens.
    Science. 1996 Nov 15;274(5290):1208-11 PMID: 8895473
  14. Proliferation of mutators in A cell population.
    J Bacteriol. 1997 Jan;179(2):417-22 PMID: 8990293
  15. Role of mutator alleles in adaptive evolution.
    Nature. 1997 Jun 12;387(6634):700-2 PMID: 9192893
  16. Highly variable mutation rates in commensal and pathogenic Escherichia coli.
    Science. 1997 Sep 19;277(5333):1833-4 PMID: 9324769
  17. Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains.
    J Infect Dis. 1998 Mar;177(3):642-50 PMID: 9498443
  18. Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin.
    Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8922-6 PMID: 9671780
  19. Shigella and enteroinvasive Escherichia coli strains are derived from distinct ancestral strains of E. coli.
    Microbiology. 1998 Sep;144 ( Pt 9):2667-72 PMID: 9782516
  20. The link between phylogeny and virulence in Escherichia coli extraintestinal infection.
    Infect Immun. 1999 Feb;67(2):546-53 PMID: 9916057
  21. Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
    Genetics. 1999 Jun;152(2):485-93 PMID: 10353893
  22. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.
    Science. 2000 May 19;288(5469):1251-4 PMID: 10818002
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.184.2.605-609.2002
Published
2002-01-00
Pages
605-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC139564
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.184.2.605-609.2002 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2