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PMID: 8524839 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

cAMP-dependent SOS induction and mutagenesis in resting bacterial populations.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 92 ·No. 25 ·1995-12-05 ·Pages 11736-40

Taddei F, Matic I, Radman M

Abstract

The inducible SOS system increases the survival of bacteria exposed to DNA-damaging agents by increasing the capacity of error-free and error-prone DNA repair systems. The inducible mutator effect is expected to contribute to the adaptation of bacterial populations to these adverse life conditions by increasing their genetic variability. The evolutionary impact of the SOS system would be even greater if it was also induced under conditions common in nature, such as in resting bacterial populations. The results presented here show that SOS induction and mutagenesis do occur in bacteria in aging colonies on agar plates. The observed SOS induction and mutagenesis are controlled by the LexA repressor and are RecA- and cAMP-dependent.

MeSH Terms
Bacterial Proteins/metabolism Cyclic AMP/metabolism DNA Repair Drug Resistance, Microbial/genetics Escherichia coli/genetics,growth & development Mutagenesis Rifampin/pharmacology SOS Response, Genetics Serine Endopeptidases
Chemicals
Bacterial Proteins LexA protein, Bacteria Cyclic AMP Serine Endopeptidases Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taddei F
Laboratoire de Mutagénèse, Institut Jacques Monod, Paris, France.
Matic I
Radman M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.92.25.11736
Published
1995-12-05
Pages
11736-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC40477
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.92.25.11736 PMC Full Text View journal details
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