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PMID: 1176612 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Association of Pseudomonas cepacia with chronic granulomatous disease.

Journal of clinical microbiology ·Vol. 1 ·No. 5 ·1975-05-00 ·Pages 425-8

Bottone EJ, Douglas SD, Rausen AR, Keusch GT

Abstract

Pseudomonas cepacia was recovered from a number of infected sites in three patients with chronic granulomatous disease of childhood. The organisms were identified on the basis of their oxidative utilization of a variety of carbohydrates and their positive beta-galactosidase and oxidase activities. They were resistant to most antimicrobial agents and moderately susceptible to chloramphenicol. Peripheral blood leukocytes isolated from two siblings with chronic granulomatous disease, including one of the patients in this series, failed to kill P. cepacia in vitro. Prolonged prophylactic and antimicrobial therapy may well have played a significant role in the colonization and infection of these patients with P. cepacia.

MeSH Terms
Blood Bactericidal Activity Child Child, Preschool Drug Resistance, Microbial Granulomatous Disease, Chronic/microbiology Humans Leukocytes/immunology Male Phagocyte Bactericidal Dysfunction/microbiology Pseudomonas/classification,immunology,isolation & purification,pathogenicity
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bottone E J
Douglas S D
Rausen A R
Keusch G T
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.1.5.425-428.1975
Published
1975-05-00
Pages
425-8
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC275137
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.1.5.425-428.1975 PMC Full Text View journal details
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