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PMID: 11868933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Insights into the immunopathogenesis of multiple sclerosis.

Immunologic research ·Vol. 25 ·No. 1 ·2002-00-00 ·Pages 27-51

Hellings N, Raus J, Stinissen P

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to be an autoimmune disease that results from aberrant immune responses to CNS antigens. T cells are considered to be crucial in orchestrating an immunopathological cascade that results in damage to the myelin sheath. This review summarizes the currently available data supporting the idea that myelin reactive T cells are actively involved in the immunopathogenesis of MS. Some of the therapeutic strategies for MS are discussed with a focus on immunotherapies that aim to specifically target the myelin reactive T cells.

MeSH Terms
Animals Autoantigens Autoimmunity Central Nervous System/immunology Cytokines/biosynthesis Encephalomyelitis, Autoimmune, Experimental/etiology,immunology HLA-DR2 Antigen/genetics Humans Immunotherapy Inflammation Mediators/metabolism Lymphocyte Activation Models, Immunological Multiple Sclerosis/etiology,immunology,therapy Myelin Sheath/immunology Receptors, Antigen, T-Cell/immunology T-Lymphocytes/immunology Vaccination
Chemicals
Autoantigens Cytokines HLA-DR2 Antigen Inflammation Mediators Receptors, Antigen, T-Cell
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hellings Niels
Biomedical Research Institute, Limburg University Center, School for Life Sciences, Transnational University Diepenbeek, Belgium.
Raus Jef
Stinissen Piet
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:25:1:27
Published
2002-00-00
Pages
27-51
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1385/IR:25:1:27 View journal details
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