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PMID: 1187962 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Chlorpromazine effects on brain activity (contingent negative variation) and reaction time in normal women.

Psychopharmacologia ·Vol. 43 ·No. 3 ·1975-09-17 ·Pages 293-5

Tecce JJ, Cole JO, Savignano-Bowman J

Abstract

Electrical brain activity (contingent negative variation of CNV) and psychomotor behavior (reaction time or RT) were measured after 50 mg of chlorpromazine (CPZ) or placebo were given orally to 28 normal women. CPZ reduced CNV 2 and 3 hrs post-drug and slowed RT 3 hrs post-drug. CNV amplitude appears to be an accurate indicator of drug-produced changes in alertness.

MeSH Terms
Adult Arousal/drug effects Brain/drug effects,physiology Chlorpromazine/pharmacology Contingent Negative Variation/drug effects Electroencephalography Electrooculography Electrophysiology/drug effects Female Humans Reaction Time/drug effects Time Factors
Chemicals
Chlorpromazine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tecce J J
Cole J O
Savignano-Bowman J
References (6)
6 references, click to expand
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    Nature. 1964 Jul 25;203:380-4 PMID: 14197376
  4. Effect of minor and major tranquilizers on somatosensory evoked potentials.
    Psychopharmacologia. 1972;24(3):347-58 PMID: 4556217
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  6. Psychophysiologic responses of schizophrenics to drugs.
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Article Info
Journal
Psychopharmacologia
Abbr.
Psychopharmacologia
DOI
10.1007/BF00429268
Published
1975-09-17
Pages
293-5
Language
English
Region
Germany
NLM ID
7609417
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00429268
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