Activated macrophages release a factor which lyses malignant cells but not normal cells.

The Journal of experimental medicine ·Vol. 142 ·No. 6 ·1975-12-01 ·Pages 1600-5

Currie GA, Basham C

Abstract

When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic effect is mediated by a labile supernatant product.

MeSH Terms

Animals Antineoplastic Agents/analysis,therapeutic use Ascitic Fluid/cytology Cell Line Cytotoxicity Tests, Immunologic Endotoxins Macrophages/analysis,immunology Rats Rats, Inbred Strains Salmonella typhi Sarcoma, Experimental/immunology

Chemicals

Antineoplastic Agents Endotoxins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Currie G A

Basham C

References (12)

12 references, click to expand

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Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells.
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.142.6.1600

Published

1975-12-01

Pages

1600-5

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2190066

Subset

External Links

PubMed source DOI: 10.1084/jem.142.6.1600 PMC Full Text View journal details

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