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PMID: 12061891 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Phagosome maturation: aging gracefully.

The Biochemical journal ·Vol. 366 ·No. Pt 3 ·2002-09-15 ·Pages 689-704

Vieira OV, Botelho RJ, Grinstein S

Abstract

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic leucocytes. The initial stage of the elimination process is the internalization of the particles into a plasma membrane-derived vacuole known as the phagosome. Such nascent phagosomes, however, lack the ability to kill pathogens or to degrade the ingested targets. These properties are acquired during the course of phagosomal maturation, a complex sequence of reactions that result in drastic remodelling of the phagosomal membrane and contents. The determinants and consequences of the fusion and fission reactions that underlie phagosomal maturation are the topic of this review.

MeSH Terms
Aging Animals Calcium/metabolism Cell Line Cytoskeleton/metabolism Endocytosis Endoplasmic Reticulum/metabolism Hydrogen-Ion Concentration Leukocytes/metabolism Macrophages/physiology Membrane Proteins/metabolism Mice Mycobacterium/metabolism Phagocytosis Phagosomes/chemistry,metabolism Phosphatidylinositol 3-Kinases/metabolism Phosphatidylinositols/metabolism SNARE Proteins Salmonella/metabolism Time Factors Vesicular Transport Proteins rab GTP-Binding Proteins/metabolism
Chemicals
Membrane Proteins Phosphatidylinositols SNARE Proteins Vesicular Transport Proteins Phosphatidylinositol 3-Kinases rab GTP-Binding Proteins Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vieira Otilia V
Programme in Cell Biology, Hospital for Sick Children and Department of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada.
Botelho Roberto J
Grinstein Sergio
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/BJ20020691
Published
2002-09-15
Pages
689-704
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1222826
Subset
IM
External Links
PubMed source DOI: 10.1042/BJ20020691 PMC Full Text View journal details
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