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PMID: 12097503 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 22 ·No. 13 ·2002-07-01 ·Pages 5516-24

Hatta T, Moriyama K, Nakashima K, Taga T, Otani H

Abstract

The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells. Furthermore, chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp130-mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum.

MeSH Terms
Animals Antigens, CD/genetics,physiology Cell Division/drug effects Cell Movement/drug effects Cerebral Cortex/anatomy & histology,cytology,embryology Cerebral Ventricles/cytology,drug effects,embryology Cytokine Receptor gp130 Embryo, Mammalian/cytology,drug effects Female Growth Inhibitors/administration & dosage,pharmacology Interleukin-6 Leukemia Inhibitory Factor Lymphokines/administration & dosage,pharmacology Membrane Glycoproteins/genetics,physiology Mice Mice, Inbred ICR Mice, Knockout Microinjections Mitosis Neurons/drug effects,physiology Phenotype Signal Transduction Stem Cells/physiology Telencephalon/cytology,embryology,metabolism
Chemicals
Antigens, CD Growth Inhibitors Il6st protein, mouse Interleukin-6 Leukemia Inhibitory Factor Lif protein, mouse Lymphokines Membrane Glycoproteins Cytokine Receptor gp130
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hatta Toshihisa
Department of Anatomy, Shimane Medical University, Izumo 693-8501, Japan. [email protected]
Moriyama Kenji
Nakashima Kinichi
Taga Tetsuya
Otani Hiroki
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
20026548
Email
[email protected]
Published
2002-07-01
Pages
5516-24
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6758239
Subset
IM
External Links
PubMed source DOI: 20026548 PMC Full Text View journal details
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