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PMID: 12151331 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Dealing with osmostress through MAP kinase activation.

EMBO reports ·Vol. 3 ·No. 8 ·2002-08-00 ·Pages 735-40

de Nadal E, Alepuz PM, Posas F

Abstract

In response to changes in the extracellular environment, cells coordinate intracellular activities to maximize their probability of survival and proliferation. Eukaryotic cells, from yeast to mammals, transduce diverse extracellular stimuli through the cell by multiple mitogen-activated protein kinase (MAPK) cascades. Exposure of cells to increases in extracellular osmolarity results in rapid activation of a highly conserved family of MAPKs, known as stress-activated MAPKs (SAPKs). Activation of SAPKs is essential for the induction of adaptive responses required for cell survival upon osmostress. Recent studies have begun to shed light on the broad effects of SAPK activation in the modulation of several aspects of cell physiology, ranging from the control of gene expression to the regulation of cell division.

MeSH Terms
Animals Cell Cycle Down-Regulation Enzyme Activation Fungal Proteins/metabolism MAP Kinase Signaling System Models, Biological Osmotic Pressure Protein Biosynthesis RNA Processing, Post-Transcriptional Signal Transduction Transcription, Genetic
Chemicals
Fungal Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
de Nadal Eulàlia
Cell Signaling Unit, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
Alepuz Paula M
Posas Francesc
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1093/embo-reports/kvf158
Published
2002-08-00
Pages
735-40
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1084212
Subset
IM
External Links
PubMed source DOI: 10.1093/embo-reports/kvf158 PMC Full Text View journal details
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