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PMID: 12212784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease.

Journal of molecular neuroscience : MN ·Vol. 19 ·No. 1-2 ·2002-00-00 ·Pages 213-7

Bendheim PE, Poeggeler B, Neria E, Ziv V, Pappolla MA, Chain DG

Abstract

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.

MeSH Terms
Alzheimer Disease/drug therapy,metabolism Amyloid beta-Peptides/drug effects,metabolism Animals Antioxidants/therapeutic use Humans Indoles/pharmacology,therapeutic use Neurofibrillary Tangles/drug effects,metabolism Neuroprotective Agents/pharmacology,therapeutic use Oxidative Stress/drug effects
Chemicals
Amyloid beta-Peptides Antioxidants Indoles Neuroprotective Agents indolepropionic acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bendheim Paul E
Minden BioPharmaceuticals, Ltd, Jerusalem, Israel. [email protected]
Poeggeler Burkhard
Neria Eyal
Ziv Vivi
Pappolla Miguel A
Chain Daniel G
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Article Info
Journal
Journal of molecular neuroscience : MN
Abbr.
J Mol Neurosci
ISSN
0895-8696
DOI
10.1007/s12031-002-0036-0
Email
[email protected]
Published
2002-00-00
Pages
213-7
Language
English
Region
United States
NLM ID
9002991
Subset
IM
External Links
PubMed source DOI: 10.1007/s12031-002-0036-0 View journal details
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