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PMID: 12379821 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Peroxynitrite in myocardial ischemia-reperfusion injury.

Heart failure reviews ·Vol. 7 ·No. 4 ·2002-10-00 ·Pages 359-69

Lalu MM, Wang W, Schulz R

Abstract

Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion. This review surveys evidence supporting both sides and proposes that peroxynitrite is a dichotomous molecule with beneficial and detrimental effects on the reperfused heart. Its toxic effects are mediated by modification and activation of a variety of targets (including poly (ADP) ribose synthetase and matrix metalloproteinases) while its beneficial effects are primarily mediated through its reaction with thiols, resulting in the formation of NO donor compounds (S-nitrosothiols).

MeSH Terms
Humans Matrix Metalloproteinases/metabolism Myocardial Reperfusion Injury/metabolism Nitric Oxide/metabolism Peroxynitrous Acid/metabolism Poly(ADP-ribose) Polymerases/metabolism
Chemicals
Peroxynitrous Acid Nitric Oxide Poly(ADP-ribose) Polymerases Matrix Metalloproteinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lalu Manoj M
Department of Pharmacology, Cardiovascular Research Group, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Wang Wenjie
Schulz Richard
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Article Info
Journal
Heart failure reviews
Abbr.
Heart Fail Rev
ISSN
1382-4147
DOI
10.1023/a:1020766502316
Published
2002-10-00
Pages
359-69
Language
English
Region
United States
NLM ID
9612481
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1020766502316 View journal details
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