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PMID: 1244422 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Studies on the role of the host immune response in recovery from Friend virus leukemia. I. Antiviral and antileukemia cell antibodies.

The Journal of experimental medicine ·Vol. 143 ·No. 1 ·1976-01-01 ·Pages 73-84

Chesebro B, Wehrly K

Abstract

The humoral immune response to Friend virus leukemia was studied in congenic F1 mice differing in their incidence of recovery from leukemia. Antiviral neutralizing antibodies rose in titer in vivo concurrently with disappearance of viremia and fall in spleen virus levels. Cytotoxic antileukemia cell antibodies also appeared at this time. Passive transfer of these antibodies could inactivate low numbers of leukemia cells in vivo; however, mice of both high and low recovery genotypes produced antibodies in equal titer and recovered from viral infection in spite of striking differences in recovery from leukemic splenomegaly. Mice lacking C57BL genes did not produce antibodies or recover from viremia except in rare instances. Recovery from splenomegaly was found to be influenced by three or more C57BL genes independent of the H-2 complex.

MeSH Terms
Animals Antibodies, Neoplasm Antibodies, Viral Cytotoxicity Tests, Immunologic Friend murine leukemia virus/immunology,isolation & purification Genes Immunization, Passive Leukemia, Experimental/immunology,microbiology,therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred Strains Neutralization Tests
Chemicals
Antibodies, Neoplasm Antibodies, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chesebro B
Wehrly K
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35 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.143.1.73
Published
1976-01-01
Pages
73-84
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190092
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.143.1.73 PMC Full Text View journal details
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