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PMID: 12463737 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Do inflammatory cells participate in mammary gland involution?

Journal of mammary gland biology and neoplasia ·Vol. 7 ·No. 2 ·2002-04-00 ·Pages 163-76

Monks J, Geske FJ, Lehman L, Fadok VA

Abstract

The processes by which the involuting mammary gland clears residual milk and milk fat, as well as apoptotic cells, have gone largely unstudied in the modern literature. Here we review the evidence for and against the involvement of professional phagocytes of hematopoietic lineage in this process. Additionally we present evidence that mammary epithelial cells themselves are capable of phagocytosis and may be responsible for the majority of apoptotic cell and residual milk clearance during murine involution. In this scheme these cells regulate their cytokine production in response to apoptotic cells in a manner similar to other cells, including macrophages. The ensuing model describes a process of involution that actively suppresses an inflammatory response in the gland, allowing for effective tissue remodeling and damage prevention.

MeSH Terms
Animals Breast/pathology Humans Inflammation/pathology Lactation/physiology Milk/cytology,metabolism Phagocytes/pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Monks Jenifer
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA.
Geske F Jon
Lehman Lisa
Fadok Valerie A
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
Published
2002-04-00
Pages
163-76
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NIGMS NIH HHS · GM 60449 · United States
NICHD NIH HHS · HD 38129 · United States
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