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PMID: 12474141 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A locus for migraine without aura maps on chromosome 14q21.2-q22.3.

American journal of human genetics ·Vol. 72 ·No. 1 ·2003-01-00 ·Pages 161-7

Soragna D, Vettori A, Carraro G, Marchioni E, Vazza G, Bellini S, Tupler R, Savoldi F, Mostacciuolo ML

Abstract

Migraine is a common and disabling neurological disease of unknown origin characterized by a remarkable clinical variability. It shows strong familial aggregation, suggesting that genetic factors are involved in its pathogenesis. Different approaches have been used to elucidate this hereditary component, but a unique transmission model and causative gene(s) have not yet been identified. We report clinical and molecular data from a large Italian pedigree in which migraine without aura (MO) segregates as an autosomal dominant trait. After exclusion of any association between MO and the known familial hemiplegic migraine and migraine with aura loci, we performed a genomewide linkage analysis using 482 polymorphic microsatellite markers. We obtained significant evidence of linkage between the MO phenotype and the marker D14S978 on 14q22.1 (maximum two-point LOD score of 3.70, at a recombination fraction of 0.01). Multipoint parametric analysis (maximum LOD score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a region of 10 cM flanked by markers D14S1027 and D14S980 on chromosome 14q21.2-q22.3. These results indicate the first evidence of a genetic locus associated with MO on chromosome 14.

MeSH Terms
Chromosome Mapping Chromosomes, Human, Pair 14/genetics Female Genes, Dominant/genetics Humans Italy Lod Score Male Microsatellite Repeats/genetics Middle Aged Migraine without Aura/genetics Pedigree
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Soragna D
Neurological Institute C. Mondino I.R.C.C.S., Department of Neurological Sciences, University of Pavia, Pavia, Italy. [email protected]
Vettori A
Carraro G
Marchioni E
Vazza G
Bellini S
Tupler R
Savoldi F
Mostacciuolo M L
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/345298
Email
[email protected]
Published
2003-01-00
Epub
2002-00-09
Pages
161-7
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC378621
Subset
IM
Grants
Telethon · E.1252 · Italy
Databases
OMIM
112262, 141500, 157300, 176804, 300125, 600225, 601011, 602481, 606439, 606687
External Links
PubMed source DOI: 10.1086/345298 PMC Full Text View journal details
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