CORG: a database for COmparative Regulatory Genomics.

Nucleic acids research ·Vol. 31 ·No. 1 ·2003-01-01 ·Pages 55-7

Dieterich C, Wang H, Rateitschak K, Luz H, Vingron M

Abstract

Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.

MeSH Terms

Animals Conserved Sequence Databases, Nucleic Acid Gene Expression Regulation Genome, Human Genomics Humans Internet Mice Regulatory Sequences, Nucleic Acid Sequence Alignment/methods Sequence Analysis, DNA/methods Transcription, Genetic

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Dieterich C

Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany. [email protected]

Wang H

Rateitschak K

Luz H

Vingron M

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

1362-4962

DOI

10.1093/nar/gkg007

[email protected]

Published

2003-01-01

Pages

55-7

Language

English

Region

England

NLM ID

0411011

PMCID

PMC165454

Subset

External Links

PubMed source DOI: 10.1093/nar/gkg007 PMC Full Text View journal details

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