Induction of erythromycin resistance in Staphyloccus aureus by erythromycin derivatives.

Antimicrobial agents and chemotherapy ·Vol. 9 ·No. 1 ·1976-01-00 ·Pages 128-30

Pestka S, Vince R, LeMahieu R, Weiss F, Fern L, Unowsky J

Abstract

The ability of 53 erythromycin analogues to induce resistance to erythromycin in Staphlococcus aureus was evaluated. Only derivatives with antibacterial activity induced resistance, although some antibacterial compounds did not induce resistance. No derivatives without antibacterial activity but with ability to induce resistance were found.

MeSH Terms

Clindamycin/pharmacology Drug Resistance, Microbial Erythromycin/analogs & derivatives,pharmacology Lincomycin/pharmacology Staphylococcus aureus/drug effects

Chemicals

Clindamycin Erythromycin Lincomycin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Pestka S

Vince R

LeMahieu R

Weiss F

Fern L

Unowsky J

References (15)

15 references, click to expand

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Genetics of resistance to macrolide antibiotics and lincomycin in natural isolates of Streptococcus pyogenes.
Mol Gen Genet. 1974;135(4):349-67 PMID: 4618889
Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus.
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Antimicrob Agents Chemother. 1976 Jan;9(1):131-6 PMID: 769668
Correlation of effects of erythromycin analogues on intact bacteria and on [14C]erythromycin binding to Escherichia coli ribosomes.
Antimicrob Agents Chemother. 1974 Oct;6(4):489-91 PMID: 4157350
Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction.
J Bacteriol. 1971 Jun;106(3):835-47 PMID: 4397638
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Proc Natl Acad Sci U S A. 1971 Apr;68(4):856-60 PMID: 5279527
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.9.1.128

Published

1976-01-00

Pages

128-30

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429486

Subset

External Links

PubMed source DOI: 10.1128/AAC.9.1.128 PMC Full Text View journal details

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Induction of erythromycin resistance in Staphyloccus aureus by erythromycin derivatives.

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