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PMID: 12634120 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Application of genomics to toxicology research.

Environmental health perspectives ·Vol. 110 Suppl 6 ·2002-12-00 ·Pages 919-23

Thomas RS, Rank DR, Penn SG, Zastrow GM, Hayes KR, Hu T, Pande K, Lewis M, Jovanovich SB, Bradfield CA

Abstract

Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.

MeSH Terms

Animals Disease Models, Animal Environmental Pollutants/adverse effects Forecasting Gene Expression Regulation Genomics Humans Oligonucleotide Array Sequence Analysis Polymorphism, Genetic Toxicity Tests Toxicology/trends

Chemicals

Environmental Pollutants

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Thomas Russell S

McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin, USA. [email protected]

Rank David R

Penn Sharron G

Zastrow Gina M

Hayes Kevin R

Hu Tianhua

Pande Kalyan

Lewis Mark

Jovanovich Stevan B

Bradfield Christopher A

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Article Info

Journal

Environmental health perspectives

Abbr.

Environ Health Perspect

ISSN

0091-6765

DOI

10.1289/ehp.02110s6919

[email protected]

Published

2002-12-00

Pages

919-23

Language

English

Region

United States

NLM ID

0330411

PMCID

PMC1241273

Subset

Grants

NCI NIH HHS · CA07175 · United States

NCI NIH HHS · T32CA09681 · United States

NIEHS NIH HHS · ES05703 · United States

NIEHS NIH HHS · R01 ES005703 · United States

NIGMS NIH HHS · GM23750 · United States

External Links

PubMed source DOI: 10.1289/ehp.02110s6919 PMC Full Text View journal details

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Application of genomics to toxicology research.

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