Genetic analysis of antisuppressor mutants in the fission yeast Schizosaccharomyces pombe.

Molecular & general genetics : MGG ·Vol. 142 ·No. 4 ·1976-12-31 ·Pages 251-61

Thuriaux P, Minet M, Hofer F, Leupold U

Abstract

Fourteen unlinked sin genes could be mutated to recessive antisuppressor alleles preventing the expression of suppressors in the fission yeast Schizosaccharomyces pombe. cyh1 alleles, resistant to the ribosomal inhibitor cycloheximide, also have some antisuppressor effect. The genetical and physiological characterization of these mutants is consistent with the hypothesis that they affect components of the messenger RNA translation machinery such as tRNA modifying enzymes or ribosomal proteins.

MeSH Terms

Alleles Ascomycota/drug effects Cycloheximide/pharmacology Drug Resistance, Microbial Genes, Recessive Genetic Linkage Genotype Mutation Phenotype Protein Biosynthesis RNA, Messenger Ribosomal Proteins Ribosomes/drug effects Schizosaccharomyces/drug effects Suppression, Genetic

Chemicals

RNA, Messenger Ribosomal Proteins Cycloheximide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thuriaux P

Minet M

Hofer F

Leupold U

References (13)

13 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00271250

Published

1976-12-31

Pages

251-61

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00271250

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Genetic analysis of antisuppressor mutants in the fission yeast Schizosaccharomyces pombe.

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