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PMID: 127645 Published · ppublish English Journal Article

H-rosette formation in T-cell-proliferative diseases.

British medical journal ·Vol. 4 ·No. 5993 ·1975-11-15 ·Pages 381-3

Sheldon PJ, Holborow EJ

Abstract

In health up to 6% of human lymphocytes will form rosettes with homologous group O rhesus-negative erythrocytes (H rosettes). Increased numbers of H rosettes were found in T-cell-proliferative diseases-- namely, infectious mononucleosis, Sézary's syndrome, and T-cell leukaemia. H-rosette formation is thus a marker for a subpopulation of T lymphocytes, and this easily performed test of T-cell activation may have clinical value in characterising changes in blood lymphocyte populations in disease.

MeSH Terms
ABO Blood-Group System Colchicine/pharmacology Cytochalasin B/pharmacology Humans Immune Adherence Reaction Infectious Mononucleosis/immunology Isoantibodies Leukemia, Lymphoid/immunology Lymphatic Diseases/immunology Lymphocyte Activation Lymphocyte Culture Test, Mixed T-Lymphocytes/immunology Vinblastine/pharmacology
Chemicals
ABO Blood-Group System Isoantibodies Cytochalasin B Vinblastine Colchicine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sheldon P J
Holborow E J
References (25)
25 references, click to expand
  1. Human T lymphocytes form rosettes with autologous and allogeneic human red blood cells.
    Clin Immunol Immunopathol. 1975 Mar;3(4):471-5 PMID: 1090401
  2. Lymphocyte subpopulations. Human red blood cell rosettes.
    Clin Exp Immunol. 1975 May;20(2):311-22 PMID: 2404
  3. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukaemia.
    Lancet. 1971 Oct 9;2(7728):788-91 PMID: 4106607
  4. Immunoglobulins on the surface of human lymphocytes.
    Lancet. 1971 Oct 16;2(7729):850-2 PMID: 4106875
  5. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.
    J Exp Med. 1972 Aug 1;136(2):207-15 PMID: 4114496
  6. Characterisation of malignant mediastinal lymphoid neoplasm (Sternberg sarcoma) as thymic in origin.
    Lancet. 1973 Jan 13;1(7794):74-7 PMID: 4118652
  7. Thymic origin of atypical lymphoid cells in infectious mononucleosis.
    Lancet. 1973 May 26;1(7813):1153-5 PMID: 4123541
  8. Thymus-derived proliferating lymphocytes in chronic lymphocytic leukaemia.
    Lancet. 1973 Aug 4;2(7823):263-4 PMID: 4124455
  9. Phytohemagglutin and concanavalin A: probes for murine 'T' cell activivation and differentiation.
    Transplant Rev. 1972;11:60-86 PMID: 4129423
  10. Cell surface localized IgM-kappa immunoglobulin reactivity in a case of chronic lymphocytic leukaemia.
    Clin Exp Immunol. 1970 Mar;6(3):421-8 PMID: 4191826
  11. Rosetting of human red blood cells to thymocytes and thymus-derived cells.
    Clin Exp Immunol. 1973 Nov;15(3):385-92 PMID: 4202949
  12. Indications of the thymus-derived nature of the proliferating cells in six patients with Sézary's syndrome.
    N Engl J Med. 1973 Aug 16;289(7):341-4 PMID: 4268776
  13. Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes.
    J Exp Med. 1973 Dec 1;138(6):1365-78 PMID: 4357682
  14. Properties of the Sezary lymphoid cell. An ultrastructural analysis.
    Mayo Clin Proc. 1974 Aug;49(8):567-74 PMID: 4369078
  15. Cytokinesis: filaments in the cleavage furrow.
    Exp Cell Res. 1968 Oct;53(1):272-6 PMID: 4387145
  16. Thymus-derived rosette-forming cells.
    N Engl J Med. 1973 May 17;288(20):1072-3 PMID: 4540498
  17. Human T lymphocyte receptors for sheep erythrocytes: conditions for binding including inhibition by cytochalasin B.
    J Immunol. 1974 Feb;112(2):862-5 PMID: 4544364
  18. Studies on synovial fluid lymphocytes in rheumatoid arthritis.
    Ann Rheum Dis. 1974 Nov;33(6):509-14 PMID: 4548344
  19. T- and B-cell subpopulations in infectious mononucleosis.
    Clin Exp Immunol. 1974 Sep;18(1):1-11 PMID: 4549622
  20. T cell surface markers on lymphoblasts from acute lymphocytic leukemia.
    J Immunol. 1973 Oct;111(4):1257-60 PMID: 4580669
  21. Childhood lymphoblastic lymphoma, a cancer of thymus-derived lymphocytes.
    Cancer Res. 1974 Mar;34(3):521-5 PMID: 4590920
  22. Immunological studies in a case of T-cell leukaemia.
    J Clin Pathol. 1974 Nov;27(11):851-9 PMID: 4613733
  23. Infectious mononucleosis: model for self-limiting lymphoproliferation.
    Lancet. 1975 Apr 12;1(7911):846-9 PMID: 48066
  24. Binding of sheep red blood cells to a large population of human lymphocytes.
    Nature. 1971 Apr 23;230(5295):531-2 PMID: 4927757
  25. Vinblastine and griseofulvin reversibly disrupt the living mitotic spindle.
    Science. 1968 May 17;160(3829):770-2 PMID: 5689568
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.4.5993.381
Published
1975-11-15
Pages
381-3
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1675253
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.4.5993.381 PMC Full Text
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