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PMID: 12773371 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity.

The EMBO journal ·Vol. 22 ·No. 11 ·2003-06-02 ·Pages 2546-51

Granucci F, Zanoni I, Feau S, Ricciardi-Castagnoli P

Abstract

Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.

MeSH Terms
Animals B-Lymphocytes/immunology Cell Communication Cell Differentiation Dendritic Cells/cytology,immunology Humans Immunity, Innate Interleukin-2/physiology Killer Cells, Natural/immunology Models, Immunological T-Lymphocytes/immunology
Chemicals
Interleukin-2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Granucci Francesca
University of Milano-Bicocca, Department of Biotechnology and Bioscience, Milan, Italy.
Zanoni Ivan
Feau Sonia
Ricciardi-Castagnoli Paola
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/cdg261
Published
2003-06-02
Pages
2546-51
Language
English
Region
England
NLM ID
8208664
PMCID
PMC156758
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/cdg261 PMC Full Text View journal details
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