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PMID: 12819904 Published · ppublish English Letter Research Support, Non-U.S. Gov't

Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.

Diabetologia ·Vol. 46 ·No. 7 ·2003-07-00 ·Pages 1021-3

Weedon MN, Gloyn AL, Frayling TM, Hattersley AT, Davey Smith G, Ben-Shlomo Y

Abstract

暂无摘要

MeSH Terms

Adult Diabetes Mellitus, Type 2/blood,genetics Female Genetic Predisposition to Disease/genetics Humans Insulin/blood Male Polymorphism, Genetic/genetics Potassium Channels, Inwardly Rectifying/genetics Quantitative Trait Loci

Chemicals

Insulin Potassium Channels, Inwardly Rectifying

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Weedon M N

Gloyn A L

Frayling T M

Hattersley A T

Davey Smith G

Ben-Shlomo Y

References (9)

9 references, click to expand

Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture.
Arch Histol Cytol. 2001 Feb;64(1):59-67 PMID: 11310506
Of mice and men: K(ATP) channels and insulin secretion.
Recent Prog Horm Res. 2001;56:47-68 PMID: 11237225
E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.
Diabetologia. 2003 Jan;46(1):136-7 PMID: 12643262
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.
Diabetes. 2003 Feb;52(2):573-7 PMID: 12540638
K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.
Diabetes. 2002 Mar;51(3):875-9 PMID: 11872696
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Diabetes. 2003 Feb;52(2):568-72 PMID: 12540637
A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.
Diabetes. 2002 Jul;51(7):2313-6 PMID: 12086966
Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.
Diabetes. 2002 Oct;51(10):3135-8 PMID: 12351459
The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.
Diabetes. 2002 Sep;51(9):2854-60 PMID: 12196481

Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/s00125-003-1135-3

Published

2003-07-00

Epub

2003-00-18

Pages

1021-3

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/s00125-003-1135-3 View journal details

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Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.

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