Hypoxia and lung mast cells: influence of disodium cromoglycate.

Thorax ·Vol. 31 ·No. 1 ·1976-02-00 ·Pages 94-100

Mungall IP

Abstract

Rats kept in 10% O2 for three or more weeks developed mast cell hyperplasia in the lungs, especially round the alveoli and the small peripheral blood vessels, which became thickened during chronic hypoxia. There was a significant correlation between the degree of right ventricular hypertrophy (RVH) and the numbers of alveolar and small vessel mast cells. However, mast cell hyperplasia developed more slowly than RVH. Daily treatment with disodium cromoglycate failed to prevent RVH in hypoxic conditions but was associated with retardation of growth in both hypoxic and control rats. Neither acute nor chronic hypoxia increased the degree of degranulation in the lung mast cells.

MeSH Terms

Animals Cardiomegaly Cell Count Cromolyn Sodium/pharmacology Hyperplasia/pathology Hypoxia/pathology Lung/pathology Mast Cells/drug effects Pulmonary Alveoli Rats Time Factors

Chemicals

Cromolyn Sodium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Mungall I P

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30 references, click to expand

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Article Info

Journal

Thorax

Abbr.

Thorax

ISSN

0040-6376

DOI

10.1136/thx.31.1.94

Published

1976-02-00

Pages

94-100

Language

English

Region

England

NLM ID

0417353

PMCID

PMC470368

Subset

External Links

PubMed source DOI: 10.1136/thx.31.1.94 PMC Full Text View journal details

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Hypoxia and lung mast cells: influence of disodium cromoglycate.

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