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PMID: 1309854 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.

The Journal of experimental medicine ·Vol. 175 ·No. 1 ·1992-01-01 ·Pages 41-7

Pullen AM, Choi Y, Kushnir E, Kappler J, Marrack P

Abstract

Mice expressing the minor lymphocyte stimulation antigens, Mls-1a, -2a, or -3a, singly on the B10.BR background have been generated. Mls phenotypes correlate with the integration of mouse mammary tumor viruses (MTV) in the mouse genome. The open reading frames within the 3' long terminal repeats of the integrated MTVs 1, 3, 6, and 13 encode V beta 3-specific superantigens. Sequence data for these viral superantigens is presented, indicating that it is the COOH-terminal portion of the viral superantigen that interacts with the T cell receptor V beta element.

MeSH Terms
Amino Acid Sequence Animals Antigens, Viral/genetics Base Sequence Cloning, Molecular DNA/genetics,isolation & purification Genome Interleukin-2/biosynthesis Liver/immunology Mammary Tumor Virus, Mouse/genetics,immunology Mice Mice, Inbred Strains Minor Lymphocyte Stimulatory Antigens/genetics,immunology Molecular Sequence Data Oligodeoxyribonucleotides Oligonucleotides, Antisense Open Reading Frames Phenotype Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid T-Lymphocytes/immunology Transfection
Chemicals
Antigens, Viral Interleukin-2 Minor Lymphocyte Stimulatory Antigens Oligodeoxyribonucleotides Oligonucleotides, Antisense DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pullen A M
Howard Hughes Medical Institute, Denver, Colorado.
Choi Y
Kushnir E
Kappler J
Marrack P
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36 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.175.1.41
Published
1992-01-01
Pages
41-7
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2119085
Subset
IM
Grants
NIAID NIH HHS · AI-18785 · United States
NIAID NIH HHS · AI-22259 · United States
NIAID NIH HHS · AI17134 · United States
Databases
GENBANK
S40279, S75515, S75516, S75517, X63024, X63025, X63026, X63027, X63232, X63233
External Links
PubMed source DOI: 10.1084/jem.175.1.41 PMC Full Text View journal details
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