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PMID: 1314025 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Filaments of Lewy bodies contain insoluble cytoskeletal elements.

The American journal of pathology ·Vol. 140 ·No. 4 ·1992-04-00 ·Pages 809-22

Galloway PG, Mulvihill P, Perry G

Abstract

The Lewy body is an intraneuronal inclusion body that is one of the histologic hallmarks of Parkinson's disease, a degenerative disease of the brain. Ultrastructural analysis has shown that the Lewy body is composed of straight 7-20 nm filaments and amorphous elements. Previous light microscopic, immunocytochemical studies have suggested the presence of neurofilament, microtubule, ubiquitin, and paired helical filament-related epitopes in Lewy bodies. Yet the biochemical composition of the Lewy body remains incompletely elucidated. The ultrastructural and immunocytochemical similarities and differences between the Lewy body and the neurofibrillary tangle of Alzheimer's disease raise questions as to their relation to each other and possible shared mechanisms of formation. In this study the authors examine whether ultrastructural immunocytochemical analysis of Lewy bodies confirms the light microscopic data, whether the structures and epitopes of Lewy bodies share with Alzheimer's disease neurofibrillary tangles the property of insolubility in sodium dodecyl sulfate, and speculate about the subunit composition of Lewy body filaments.

MeSH Terms
Aged Cytoskeleton/metabolism,ultrastructure Humans Immunohistochemistry Lewy Bodies/metabolism,ultrastructure Microtubule-Associated Proteins/metabolism Middle Aged Neurofilament Proteins/metabolism Solubility Ubiquitins/metabolism
Chemicals
Microtubule-Associated Proteins Neurofilament Proteins Ubiquitins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Galloway P G
Department of Pathology, Children's Hospital Medical Center, Akron, Ohio.
Mulvihill P
Perry G
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1992-04-00
Pages
809-22
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886359
Subset
IM
Grants
NCI NIH HHS · 30CA43703 · United States
NIA NIH HHS · AG 07552 · United States
NIA NIH HHS · AG 09287 · United States
External Links
PubMed source PMC Full Text View journal details
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