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PMID: 1314455 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coronavirus infects and causes demyelination in primate central nervous system.

Virology ·Vol. 188 ·No. 1 ·1992-05-00 ·Pages 274-84

Murray RS, Cai GY, Hoel K, Zhang JY, Soike KF, Cabirac GF

Abstract

Two species of primates, Owl and African green monkeys, were inoculated intracerebrally with either the neurotropic mouse hepatitis virus JHM or the putative multiple sclerosis brain coronavirus isolate SD. These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.

MeSH Terms
Animals Aotidae Base Sequence Blotting, Northern Blotting, Western Central Nervous System Diseases/microbiology,pathology Chlorocebus aethiops Coronaviridae/pathogenicity,physiology Coronaviridae Infections/microbiology,pathology DNA, Viral Demyelinating Diseases/microbiology,pathology Molecular Sequence Data Polymerase Chain Reaction Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Murray R S
Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, Englewood.
Cai G Y
Hoel K
Zhang J Y
Soike K F
Cabirac G F
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Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1016/0042-6822(92)90757-g
Published
1992-05-00
Pages
274-84
Language
English
Region
United States
NLM ID
0110674
PMCID
PMC7131451
Subset
IM
External Links
PubMed source DOI: 10.1016/0042-6822(92)90757-g PMC Full Text View journal details
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