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PMID: 1316931 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7.

The Journal of experimental medicine ·Vol. 175 ·No. 6 ·1992-06-01 ·Pages 1613-21

Rudy CK, Kraus E, Palmer E, Huber BT

Abstract

Mls-1 is an endogenous superantigen that leads to in vivo deletion and in vitro stimulation of T cell receptor (TCR) V beta 6-, 7-, 8.1-, and 9-expressing cells. The MA/MyJ mouse deletes the identical set of TCR from its mature T cell repertoire; however, it does not contain Mtv-7, the murine mammary tumor provirus (MMTV), whose sag gene encodes Mls-1. Interestingly, the superantigen activity of this mouse strain segregates with a new mammary tumor provirus, Mtv-43, not seen in other inbred strains. The predicted amino acid sequence of the sag gene of Mtv-43 was compared with that of Mtv-7. Strikingly, the COOH terminus of the two molecules is very similar, while all other MMTV-encoded superantigens differ 100% in this segment.

Related Genes
Mtv Mtv-9 sag
MeSH Terms
Aging Amino Acid Sequence Animals Antibodies, Monoclonal B-Lymphocytes/immunology Base Sequence Chromosome Deletion Crosses, Genetic Genes, Viral Mammary Tumor Virus, Mouse/genetics Mice Mice, Inbred Strains Mice, Mutant Strains Minor Lymphocyte Stimulatory Antigens/analysis,genetics Molecular Sequence Data Oligodeoxyribonucleotides Polymerase Chain Reaction/methods Proviruses/genetics Receptors, Antigen, T-Cell/genetics,metabolism Sequence Homology, Nucleic Acid Species Specificity Spleen/growth & development,immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Minor Lymphocyte Stimulatory Antigens Oligodeoxyribonucleotides Receptors, Antigen, T-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rudy C K
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Kraus E
Palmer E
Huber B T
References (27)
27 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.175.6.1613
Published
1992-06-01
Pages
1613-21
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2119259
Subset
IM
Grants
NIAID NIH HHS · R0I AI-14910 · United States
Databases
GENBANK
S40279, X63226, X63227, X63228, X63229, X63230, X63231, X63232, X63233, X64541
External Links
PubMed source DOI: 10.1084/jem.175.6.1613 PMC Full Text View journal details
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