Home LiteratureArticle Details
PMID: 1319783 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Multiple sequence elements are involved in RNA 3' end formation in spleen necrosis virus.

Gene expression ·Vol. 2 ·No. 1 ·1992-00-00 ·Pages 7-18

Iwasaki K, Temin HM

Abstract

The function of the poly(A) signal in spleen necrosis virus (SNV) is dependent upon the distance between the cap site and the poly(A) site, while the function of the SV40 late poly(A) signal is independent of the distance. Deletions in the SNV poly(A) sequence do not alter the distance-dependent function. SNV/SV40 chimeric poly(A) signals show intermediate behavior between the SNV and SV40 poly(A) signals. These results indicate that multiple sequence elements are involved in the functions of either the SNV or SV40 poly(A) signals. This intermediate behavior is also observed with poly(A) signals from the mouse alpha-globin and herpes simplex virus thymidine kinase genes.

MeSH Terms
Base Sequence Chromosome Deletion DNA Mutational Analysis Molecular Sequence Data Poly A/metabolism RNA Processing, Post-Transcriptional/genetics RNA, Viral/genetics,metabolism Regulatory Sequences, Nucleic Acid Retroviridae/genetics Simian virus 40/genetics
Chemicals
RNA, Viral Poly A
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Iwasaki K
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Temin H M
References (34)
34 references, click to expand
  1. A functionally redundant downstream sequence in SV40 late pre-mRNA is required for mRNA 3'-end formation and for assembly of a precleavage complex in vitro.
    J Biol Chem. 1988 Apr 25;263(12):5780-8 PMID: 2833517
  2. Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors.
    Mol Cell Biol. 1983 Dec;3(12):2241-9 PMID: 6318091
  3. The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation.
    Cell. 1991 Feb 22;64(4):727-37 PMID: 1671761
  4. NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein.
    Biochemistry. 1990 Oct 23;29(42):9814-8 PMID: 2125483
  5. The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution.
    Cell. 1979 Nov;18(3):875-82 PMID: 519760
  6. The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.
    Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2108-12 PMID: 1848693
  7. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
    Anal Biochem. 1984 Feb;137(1):266-7 PMID: 6329026
  8. A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):3949-53 PMID: 2987956
  9. Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components.
    J Virol. 1985 Aug;55(2):431-41 PMID: 2991567
  10. High mutation rate of a spleen necrosis virus-based retrovirus vector.
    Mol Cell Biol. 1986 Dec;6(12):4387-95 PMID: 3796606
  11. Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.
    Mol Cell Biol. 1986 Dec;6(12):4611-23 PMID: 2879221
  12. How the messenger got its tail: addition of poly(A) in the nucleus.
    Trends Biochem Sci. 1990 Jul;15(7):277-81 PMID: 1974368
  13. Inhibition of intractable nucleases with ribonucleoside--vanadyl complexes: isolation of messenger ribonucleic acid from resting lymphocytes.
    Biochemistry. 1979 Nov 13;18(23):5143-9 PMID: 497174
  14. Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.
    Genes Dev. 1990 May;4(5):764-76 PMID: 2379828
  15. Polyadenylation of mRNA precursors.
    Biochim Biophys Acta. 1988 May 6;950(1):1-12 PMID: 2896017
  16. Poly(A) signals.
    Cell. 1991 Feb 22;64(4):671-4 PMID: 1671760
  17. Proximity to the promoter inhibits recognition of cauliflower mosaic virus polyadenylation signal.
    Nature. 1990 Jul 5;346(6279):81-4 PMID: 2366867
  18. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
    Mol Cell Biol. 1982 Sep;2(9):1044-51 PMID: 6960240
  19. A dissection of the cauliflower mosaic virus polyadenylation signal.
    Genes Dev. 1991 Jan;5(1):141-9 PMID: 1703507
  20. Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation.
    Mol Cell Biol. 1991 Mar;11(3):1624-30 PMID: 1996111
  21. Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3755-9 PMID: 226978
  22. Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):3978-82 PMID: 2408272
  23. New procedure for DNA transfection with polycation and dimethyl sulfoxide.
    Mol Cell Biol. 1984 Jun;4(6):1172-4 PMID: 6330534
  24. Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.
    J Virol. 1991 Jun;65(6):3340-3 PMID: 1851882
  25. A beginning to the biochemistry of polyadenylation.
    Trends Genet. 1988 Sep;4(9):243-5 PMID: 2853468
  26. Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences.
    Mol Cell Biol. 1989 Oct;9(10):4248-58 PMID: 2573828
  27. Occlusion of the HIV poly(A) site.
    Genes Dev. 1991 Feb;5(2):244-53 PMID: 1995416
  28. Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.
    Mol Cell Biol. 1985 Oct;5(10):2713-9 PMID: 3016512
  29. The efficiency of RNA 3'-end formation is determined by the distance between the cap site and the poly(A) site in spleen necrosis virus.
    Genes Dev. 1990 Dec;4(12B):2299-307 PMID: 1703980
  30. Moloney murine sarcoma proviral DNA is a transcriptional unit.
    Nature. 1980 Dec 25;288(5792):665-9 PMID: 6256637
  31. Determination of 3' end processing in retroelements.
    Trends Genet. 1990 Sep;6(9):276-7 PMID: 2238082
  32. Transcription termination and 3' processing: the end is in site!
    Cell. 1985 Jun;41(2):349-59 PMID: 2580642
  33. Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1441-5 PMID: 6262799
  34. Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.
    Mol Cell Biol. 1989 Nov;9(11):4951-61 PMID: 2601703
Article Info
Journal
Gene expression
Abbr.
Gene Expr
ISSN
1052-2166
Published
1992-00-00
Pages
7-18
Language
English
Region
United States
NLM ID
9200651
PMCID
PMC6057358
Subset
IM
Grants
NCI NIH HHS · P01 CA022443 · United States
NCI NIH HHS · CA-07175 · United States
NCI NIH HHS · CA-22443 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2