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PMID: 13739276 Published · ppublish English Journal Article

Lysis of brucellae by the combined action of glycine and a lysozyme-like agent from rabbit monocytes.

Journal of bacteriology ·Vol. 82 ·1961-09-00 ·Pages 342-53

RALSTON DJ, BAER BS, ELBERG SS

Abstract

Ralston, Doris J. (University of California, Berkeley), B. S. Baer, and S. S. Elberg. Lysis of brucellae by the combined action of glycine and a lysozyme-like agent from rabbit monocytes. J. Bacteriol. 82:342-353. 1961.-An acid-extractable lytic material was obtained from rabbit monocytes. It acts on a substrate in the walls of brucellae and has properties similar to egg-white lysozyme. Brucella melitensis strain Rev Is is completely resistant to this agent and also to crystalline lysozyme, but when the cells are exposed to sufficient amounts of glycine, the surface is rendered susceptible to these lytic agents. Rough type Rev Is cells are more susceptible than smooth, and the virulent B. melitensis strain 6015 is most resistant.

Keywords
BACTERIOLYSIS BRUCELLA/pharmacology GLYCINE/pharmacology LEUKOCYTES/chemistry
MeSH Terms
Animals Anti-Infective Agents, Local Bacteriolysis Brucella/pharmacology Cell Death Glycine/pharmacology Leukocytes/chemistry Monocytes Muramidase Rabbits
Chemicals
Anti-Infective Agents, Local Muramidase Glycine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
RALSTON D J
BAER B S
ELBERG S S
References (27)
27 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
Published
1961-09-00
Pages
342-53
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC279171
Subset
OM
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