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PMID: 1379855 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Calcium pools mobilized by calcium or inositol 1,4,5-trisphosphate are differentially localized in rat heart and brain.

Molecular biology of the cell ·Vol. 3 ·No. 6 ·1992-06-00 ·Pages 621-31

Verma A, Hirsch DJ, Snyder SH

Abstract

Calcium-induced calcium release (CICR) pools have been demonstrated in brain and heart microsomes biochemically and autoradiographically by the sensitivity of 45Ca2+ accumulation to Mg2+, ATP, ruthenium red, caffeine, and tetracaine. The CICR pool colocalizes with [3H]ryanodine binding sites, supporting the notion that [3H]ryanodine labels CICR pools. Sites of CICR pools in the brain contrast with those of inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ pools with reciprocal localizations between the two Ca2+ pools in several structures. Thus, in the hippocampus CA-1 is enriched in IP3-sensitive Ca2+ pools, whereas CICR pools are highest in CA-3 and the dentate gyrus. The corpus striatum and cerebellum are enriched in IP3 pools, whereas the medial septum and olfactory bulb have high CICR densities. In cardiac tissue, CICR is localized to atrial and ventricular muscle, whereas IP3 pools are concentrated in coronary vessels and cardiac conduction fibers. The reciprocal enrichment of IP3 and CICR Ca2+ pools implies differential regulation of Ca2+ hemostasis in these tissues.

MeSH Terms
Adenosine Triphosphate/physiology Anesthetics, Local/pharmacology Animals Brain/metabolism Calcium/metabolism,physiology Endoplasmic Reticulum/metabolism In Vitro Techniques Inositol 1,4,5-Trisphosphate/physiology Magnesium/physiology Male Microsomes/metabolism Muscles/metabolism Myocardium/metabolism Rats Rats, Inbred Strains Ruthenium Red/pharmacology
Chemicals
Anesthetics, Local Ruthenium Red Inositol 1,4,5-Trisphosphate Adenosine Triphosphate Magnesium Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Verma A
Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205.
Hirsch D J
Snyder S H
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Article Info
Journal
Molecular biology of the cell
Abbr.
Mol Biol Cell
ISSN
1059-1524
DOI
10.1091/mbc.3.6.621
Published
1992-06-00
Pages
621-31
Language
English
Region
United States
NLM ID
9201390
PMCID
PMC275618
Subset
IM
Grants
NIDA NIH HHS · DA-00074 · United States
NIDA NIH HHS · DA-00266 · United States
NIMH NIH HHS · MH-18501 · United States
External Links
PubMed source DOI: 10.1091/mbc.3.6.621 PMC Full Text View journal details
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