Studies on sympathetic mechanisms in isolated intestinal and vas deferens preparations.
The effects of various drugs which block sympathetic nerves have been studied in Finkleman preparations of rabbit and cat ileum. Contractile responses could be produced in many cases after the normal inhibitory responses to periarterial nerve stimulation had been blocked. In almost all cases this contractile response was abolished by ganglion-blocking drugs. The normal rabbit ileum Finkleman preparation was found to behave differently towards bretylium than do preparations taken from animals treated with reserpine. The block of the guinea-pig isolated hypogastric vas deferens preparation caused by hemicholinium HC-3 was found to be reversed in the presence of noradrenaline, histamine, or 5-hydroxytryptamine, as was the block caused by guanethidine and bretylium. The results are discussed in relation to the Burn-Rand theory of sympathetic nerve mechanism.
18 references, click to expand
-
Transmission failure in sympathetic nerves produced by hemicholinium.Br J Pharmacol Chemother. 1960 Dec;15:588-600 PMID: 13692344
-
Fluid electrodes with a rubber diaphragm.J Physiol. 1951 Dec 28;115(4):61-2 P PMID: 14898526
-
Effect of guanethidine in revealing cholinergic sympathetic fibres.Br J Pharmacol Chemother. 1961 Oct;17:245-60 PMID: 13884063
-
Postsynaptic action of HC-3 on neuromuscular transmission.Fed Proc. 1961 Jul;20:579-82 PMID: 13767309
-
Sympathetic postganglionic cholinergic fibres.Br J Pharmacol Chemother. 1960 Mar;15:56-66 PMID: 13806187
-
The peripheral cardiovascular actions of guanethidine in dogs.J Pharmacol Exp Ther. 1961 Mar;131:346-54 PMID: 13773845
-
The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA.J Physiol. 1961 Apr;156:17-34 PMID: 13705341
-
The actions of bretylium: adrenergic neurone blocking and other effects.Br J Pharmacol Chemother. 1959 Dec;14:536-48 PMID: 13803290
-
On the nature of inhibition in the intestine.J Physiol. 1930 Sep 18;70(2):145-57 PMID: 16994130
-
Lack of evidence for a cholinergic mechanism in sympathetic transmission.Nature. 1961 Jul 1;191:86 PMID: 13703591
-
Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent.Proc Soc Exp Biol Med. 1960 Apr;103:871-2 PMID: 13808193
-
Pharmacological inhibition of acetylcholine synthesis.Nature. 1956 Nov 24;178(4543):1181 PMID: 13387665
-
Pseudomotor contractures after degeneration of the facial nerve.J Physiol. 1931 Sep 18;73(1):54-66 PMID: 16994228
-
The selective accumulation of bretylium in sympathetic ganglia and their postganglionic nerves.Br J Pharmacol Chemother. 1960 Jun;15:265-70 PMID: 13803289
-
Role for ganglionic norepinephrine in sympathetic synaptic transmission.Science. 1961 Jun 9;133(3467):1822-3 PMID: 13695783
-
Augmentation of the pressor response to guanethedine by inhibition of catechol O-methyltransferase.Nature. 1961 Feb 11;189:490-1 PMID: 13786974
-
Spontaneous potential at sympathetic nerve endings in smooth muscle.J Physiol. 1962 Mar;160:446-60 PMID: 13875001
-
Postsynaptic neuromuscular block produced by hemicholinium no. 3.Fed Proc. 1961 Jul;20:569-78 PMID: 13776378
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
