The effect of bacterial endotoxin on the newborn guinea pig.
Newborn guinea pigs (less than 24 hours old) are highly susceptible to the lethal effect of endotoxin and susceptibility decreases with age. The vulnerability to endotoxin has not been attributed to hypofunction of either the adrenal gland or the reticuloendothelial system of the newborn, since prior injection of corticosteroids provides only partial protection to endotoxin and newborn guinea pigs can efficiently remove colloidal substances from the circulation. In contrast to adults, newborns do not develop a delayed inflammatory reaction following intradermal injection of endotoxin, and after intravenous challenge frequently fail to display neutropenia and sustained fever.
14 references, click to expand
-
TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.J Exp Med. 1947 Jun 30;86(1):29-38 PMID: 19871652
-
Studies on the protective power of adrenal extract and steroids against bacterial toxins in adrenalectomized rats.Ann N Y Acad Sci. 1949 Jun 27;50(Art. 6):547-51 PMID: 18141595
-
Studies on the mechanism of the Shwartzman phenomenon; similarities between reactions to endotoxins and certain reactions of bacterial allergy.J Exp Med. 1955 Apr 1;101(4):421-36 PMID: 14354110
-
Development of delayed-type hypersensitivity in guinea pig embryos.Nature. 1960 Sep 10;187:957-9 PMID: 13779031
-
A contribution to the studies on changes of energy metabolism during postnatal development. I. Development of mechanisms of body temperature regulation in rats.J Cell Comp Physiol. 1961 Jun;57:175-84 PMID: 13736451
-
Studies of the effect of bacterial endotoxins on rabbit leucocytes. I. Effect of intravenous injection of the substances with and without induction of the local Shwartzman reaction.J Exp Med. 1953 Oct;98(4):331-48 PMID: 13096659
-
[Modifications of the phagocytic power of the reticuloendothelial system as a function of age in rats and rabbits].C R Seances Soc Biol Fil. 1956 Nov 18;150(6):1075-8 PMID: 13383894
-
A study of the relationship between the fever caused by bacterial pyrogens and the fever accompanying acute infections.J Exp Med. 1948 Sep 1;88(3):267-78 PMID: 18881485
-
Influence of age upon response to meningococcal endotoxin in rabbits.Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):806-9 PMID: 13204361
-
Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.J Exp Med. 1955 Nov 1;102(5):499-516 PMID: 13271667
-
SPONTANEOUS AND ACQUIRED ACTIVE IMMUNITY TO THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES.J Exp Med. 1932 May 31;55(6):889-902 PMID: 19870039
-
The lethal effect of endotoxins on the chick embryo.J Exp Med. 1956 Aug 1;104(2):217-31 PMID: 13345967
-
Effect of cortisone on response to endotoxin in mature rabbits.Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):810-3 PMID: 13204362
-
Experimental studies on the significance of endotoxin in the pathogenesis of brucellosis.J Clin Invest. 1954 Apr;33(4):540-8 PMID: 13152193
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
