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PMID: 14035890 Published · ppublish English Journal Article

Actions of certain amines on cerebral cortical neurones.

British journal of pharmacology and chemotherapy ·Vol. 20 ·1963-06-00 ·Pages 471-90

KRNJEVIC K, PHILLIS JW

Abstract

A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of L-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action.

Keywords
CEREBRAL CORTEX DOPAMINE EPINEPHRINE LYSERGIC ACID DIETHYLAMIDE NEURONS SEROUS MEMBRANE
MeSH Terms
Amines Animals Cats Cerebral Cortex Dopamine Epinephrine Glutamic Acid Lysergic Acid Diethylamide Neurons Serotonin Serous Membrane Tryptamines gamma-Aminobutyric Acid
Chemicals
Amines Tryptamines Serotonin Glutamic Acid tryptamine gamma-Aminobutyric Acid Lysergic Acid Diethylamide Dopamine Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
KRNJEVIC K
PHILLIS J W
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1963.tb01484.x
Published
1963-06-00
Pages
471-90
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1703804
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1963.tb01484.x PMC Full Text
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