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PMID: 14060446 Published · ppublish English Journal Article

THE EFFECTS OF INHIBITORS OF MACROMOLECULAR BIOSYNTHESIS UPON THE PERSISTENT RHYTHM OF LUMINESCENCE IN GONYAULAX.

The Journal of general physiology ·Vol. 47 ·1963-09-00 ·Pages 1-12

KARAKASHIAN MW, HASTINGS JW

Abstract

Certain inhibitors of nucleic acid and protein synthesis, namely actinomycin D, mitomycin C, and puromycin, have been found to block the expression of a persistent daily rhythm of bioluminescence. The action does not inhibit luminescence per se but rather the rhythmicity. Exposure of the cells to these inhibitors for only a few hours, which might be expected to thereby delay the rhythm by a few hours, does not in fact have this effect. Chloramphenicol and amethopterin do not inhibit the rhythm. It is proposed that the functioning of the clock-like rhythmic mechanism depends upon the cell's normal ability to synthesize RNA.

Keywords
ACTINOMYCIN ANTIBIOTICS CHLORAMPHENICOL EXPERIMENTAL LAB STUDY LUMINESCENCE MASTIGOPHORA MITOMYCIN PHARMACOLOGY PUROMYCIN
MeSH Terms
Anti-Bacterial Agents Chloramphenicol Dactinomycin Dinoflagellida Eukaryota Luminescence Mitomycin Pharmacology Puromycin RNA Research
Chemicals
Anti-Bacterial Agents Dactinomycin Puromycin Mitomycin RNA Chloramphenicol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
KARAKASHIAN M W
HASTINGS J W
References (22)
22 references, click to expand
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Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
DOI
10.1085/jgp.47.1.1
Published
1963-09-00
Pages
1-12
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2195333
Subset
OM
External Links
PubMed source DOI: 10.1085/jgp.47.1.1 PMC Full Text View journal details
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