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PMID: 1417193 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs.

Annals of surgery ·Vol. 216 ·No. 4 ·1992-10-00 ·Pages 438-44; discussion 444-5

Fukushima R, Gianotti L, Alexander JW, Pyles T

Abstract

Bacterial translocation and related mortality rates were examined in previously transfused BALB/c mice that were gavaged with 14C radioisotope-labeled Escherichia coli before inflicting a 20% full-thickness flame burn. Radionuclide counts were measured in blood obtained by retro-orbital puncture 4 hours postburn, and survival was recorded for 10 days. Radionuclide counts in the blood correlated well with both radionuclide counts and numbers of viable bacterial in the tissues. Survivors had significantly less bacterial translocation as evidenced by blood radionuclide counts compared with nonsurvivors, and there was a significant inverse correlation between the degree of translocation and the length of survival. In the next experiment, the prostaglandin E (PGE) analogs misoprostol, enisoprost, or 16,16-dimethyl PGE2 were administered to transfused animals for 3 days before burn. Prostaglandin E analogs significantly reduced bacterial translocation as measured by blood radionuclide counts 4 hours postburn and improved survival. The data demonstrate that the intensity of bacterial translocation after burn injury is significantly associated with subsequent death. Improvement of survival by PGE analogs is associated with decreased bacterial translocation.

MeSH Terms
16,16-Dimethylprostaglandin E2/pharmacology Alprostadil/analogs & derivatives,pharmacology Animals Burns/drug therapy,microbiology,mortality Colony Count, Microbial Escherichia coli/growth & development Female Mice Mice, Inbred BALB C Mice, Inbred C3H Misoprostol/pharmacology Prostaglandins E, Synthetic/pharmacology
Chemicals
Prostaglandins E, Synthetic Misoprostol Alprostadil enisoprost 16,16-Dimethylprostaglandin E2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fukushima R
Department of Surgery, University of Cincinnati Medical Center 45267-0558.
Gianotti L
Alexander J W
Pyles T
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40 references, click to expand
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Article Info
Journal
Annals of surgery
Abbr.
Ann Surg
ISSN
0003-4932
DOI
10.1097/00000658-199210000-00007
Published
1992-10-00
Pages
438-44; discussion 444-5
Language
English
Region
United States
NLM ID
0372354
PMCID
PMC1242648
Subset
IM
Grants
NIAID NIH HHS · AI-12936 · United States
External Links
PubMed source DOI: 10.1097/00000658-199210000-00007 PMC Full Text View journal details
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