Home LiteratureArticle Details
PMID: 14421526 Published · ppublish English Journal Article

The effect of iproniazid and imipramine on the blood platelet 5-hydroxytrptamine level in man.

British journal of pharmacology and chemotherapy ·Vol. 15 ·1960-03-00 ·Pages 35-41

MARSHALL EF, STIRLING GS, TAIT AC, TODRICK A

Abstract

Observations are reported on the blood platelet 5-hydroxytryptamine content of six patients receiving imipramine, N-(gamma-dimethylaminopropyl)-iminodibenzyl hydrochloride. The response was a fall to a level of one-sixth of the original in three weeks, with little change thereafter. This is in sharp contrast to the action of iproniazid which caused a rise of some 200% in the blood platelet 5-hydroxytryptamine level over the same period. Imipramine in a concentration of 1 mg./ml. had no inhibitory action on 5-hydroxytryptophan decarboxylase; 8.0 mug./ml. of imipramine suppressed two-thirds of the in vitro uptake of 5-hydroxytryptamine (2.5 mug./ml.) by normal human platelets.

Keywords
BLOOD PLATELETS/metabolism IPRONIAZID/pharmacology PSYCHOPHARMACOLOGY SEROTONIN
MeSH Terms
Aromatic-L-Amino-Acid Decarboxylases Blood Platelets/metabolism Humans Imipramine Iproniazid/pharmacology Male Psychopharmacology Serotonin
Chemicals
Serotonin Iproniazid Aromatic-L-Amino-Acid Decarboxylases Imipramine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
MARSHALL E F
STIRLING G S
TAIT A C
TODRICK A
References (21)
21 references, click to expand
  1. Inhibition of 5-hydroxytryptophan decarboxylase by phenylalanine metabolites.
    Nature. 1958 Jan 18;181(4603):186-7 PMID: 13504122
  2. Release of serotonin from blood platelets by reserpine in vitro.
    J Pharmacol Exp Ther. 1957 Jul;120(3):334-9 PMID: 13476355
  3. On the mechanism of action of reserpine: effect of reserpine on capacity of tissues to bind serotonin.
    J Pharmacol Exp Ther. 1957 Apr;119(4):461-7 PMID: 13429453
  4. Fluorescence characteristics of 5-hydroxytryptamine (serotonin).
    Science. 1955 Nov 18;122(3177):972-3 PMID: 13274060
  5. Analysis of 1955-1956 population fall in New York State mental hospitals in first year of large-scale use of tranquilizing drugs.
    Am J Psychiatry. 1957 Dec;114(6):509-17 PMID: 13478768
  6. [Treatment of depressive states with an iminodibenzyl derivative (G 22355)].
    Schweiz Med Wochenschr. 1957 Aug 31;87(35-36):1135-40 PMID: 13467194
  7. Relationship of platelet serotonin to disturbances of clotting and hemostasis.
    Circulation. 1957 Mar;15(3):353-7 PMID: 13404708
  8. [On the pharmacology of tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl hydrochloride].
    Arch Int Pharmacodyn Ther. 1959 Jul 1;120:450-89 PMID: 13817386
  9. Increase of 5-hydroxytryptamine in blood platelets by isopropyl-isonicotinic acid hydrazide.
    Nature. 1958 Apr 19;181(4616):1133-4 PMID: 13541391
  10. Blood and urinary serotonin and 5-hydroxyindole acetic acid levels in schizophrenic patients and normal subjects.
    J Nerv Ment Dis. 1959 Jul;129:62-8 PMID: 13822064
  11. Some drugs used in the treatment of mental disorders.
    Am J Psychiatry. 1959 Feb;115(8):756-9 PMID: 13617516
  12. A comparative study of the effects of drugs on the arousal system of the brain.
    Br J Pharmacol Chemother. 1959 Sep;14:340-9 PMID: 13803718
  13. Further observations on vasoconstrictor substances in blood of rabbit and man.
    J Physiol. 1957 Oct 30;138(3):401-16 PMID: 13481881
  14. The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets.
    Br J Pharmacol Chemother. 1958 Mar;13(1):62-4 PMID: 13523136
  15. Acute hepatic necrosis following iproniazid therapy; value of glutamic-oxaloacetic transaminase estimation in early detection.
    Lancet. 1959 Feb 7;1(7067):282-4 PMID: 13631997
  16. 5-Hydroxytryptamine in normal human platelets.
    J Physiol. 1955 Dec 29;130(3):711-20 PMID: 13278930
  17. The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species.
    J Physiol. 1954 May 28;124(2):305-10 PMID: 13175133
  18. [Treatment of depressive states with special consideration of tofranil, a new antidepressant].
    Schweiz Med Wochenschr. 1958 Aug 2;88(31):763-7 PMID: 13580195
  19. [The influence of various drugs on the permeability-increasing effect of serotonin].
    Arch Int Pharmacodyn Ther. 1959 Feb 1;118(3-4):292-7 PMID: 13628248
  20. The estimation of 5-hydroxytryptamine (serotonin) in biological tissues.
    J Biol Chem. 1955 Jul;215(1):337-44 PMID: 14392167
  21. The Enumeration of Blood Platelets.
    J Clin Pathol. 1948 May;1(3):175-6 PMID: 16810801
Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1960.tb01207.x
Published
1960-03-00
Pages
35-41
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1481980
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1960.tb01207.x PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2