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PMID: 14500782 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 20 ·2003-09-30 ·Pages 11660-5

Brazilian National Genome Project Consortium

Abstract

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) approximately 500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.

MeSH Terms
Adaptation, Physiological Chromobacterium/genetics,physiology Genome, Bacterial Molecular Sequence Data Open Reading Frames
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brazilian National Genome Project Consortium
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.1832124100
Published
2003-09-30
Epub
2003-00-18
Pages
11660-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC208814
Subset
IM
Databases
GENBANK
AE016825
External Links
PubMed source DOI: 10.1073/pnas.1832124100 PMC Full Text View journal details
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