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PMID: 14501020 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Calpain inhibitors, a treatment for Alzheimer's disease: position paper.

Journal of molecular neuroscience : MN ·Vol. 20 ·No. 3 ·2003-00-00 ·Pages 357-62

Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O

Abstract

Calpains modulate processes that govern the function and metabolism of proteins key to the pathogenesis of Alzheimer's disease, including tau and amyloid precursor protein. Because activation of the calpain system might contribute to the impairment of synaptic transmission in Alzheimer's disease, we are currently testing the hypotheses that a treatment with calpain inhibitors might restore normal cognition and synaptic transmission in a transgenic model of Alzheimer's disease, the APP (K670N:M671L)/PS1(M146L) mouse. Findings derived from these studies will provide a novel approach to cognitive enhancement in Alzheimer's disease.

MeSH Terms

Alzheimer Disease/drug therapy,enzymology,genetics Amyloid beta-Protein Precursor/genetics,metabolism Animals Calpain/antagonists & inhibitors,metabolism Cysteine Proteinase Inhibitors/pharmacology,therapeutic use Disease Models, Animal Hippocampus/drug effects,enzymology,physiopathology Leucine/analogs & derivatives,pharmacology,therapeutic use Long-Term Potentiation/drug effects,genetics Maze Learning/drug effects,physiology Membrane Proteins/genetics,metabolism Memory Disorders/drug therapy,enzymology,genetics Mice Mice, Transgenic Organ Culture Techniques Presenilin-1 Treatment Outcome Up-Regulation/drug effects,genetics

Chemicals

Amyloid beta-Protein Precursor Cysteine Proteinase Inhibitors Membrane Proteins Presenilin-1 Calpain Leucine E 64

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Battaglia Fortunato

Department of Psychiatry, Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY 10962, USA.

Trinchese Fabrizio

Liu Shumin

Walter Sean

Nixon Ralph A

Arancio Ottavio

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14 references, click to expand

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Article Info

Journal

Journal of molecular neuroscience : MN

Abbr.

J Mol Neurosci

ISSN

0895-8696

DOI

10.1385/JMN:20:3:357

Published

2003-00-00

Pages

357-62

Language

English

Region

United States

NLM ID

9002991

Subset

External Links

PubMed source DOI: 10.1385/JMN:20:3:357 View journal details

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Calpain inhibitors, a treatment for Alzheimer's disease: position paper.

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