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PMID: 14513409 Published · ppublish English Journal Article

Localization of a gene for migraine without aura to chromosome 4q21.

American journal of human genetics ·Vol. 73 ·No. 5 ·2003-11-00 ·Pages 986-93

Björnsson A, Gudmundsson G, Gudfinnsson E, Hrafnsdóttir M, Benedikz J, Skúladóttir S, Kristjánsson K, Frigge ML, Kong A, Stefánsson K, Gulcher JR

Abstract

Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genome-wide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2 x 10(-6)).

MeSH Terms
Alleles Chromosome Mapping Chromosomes, Human, Pair 4/genetics Female Finland Humans Iceland Lod Score Male Migraine without Aura/genetics
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Björnsson Asgeir
deCODE Genetics, Reykjavik, Iceland. [email protected]
Gudmundsson Grétar
Gudfinnsson Einar
Hrafnsdóttir María
Benedikz John
Skúladóttir Svanhildur
Kristjánsson Kristleifur
Frigge Michael L
Kong Augustine
Stefánsson Kári
Gulcher Jeffrey R
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/378417
Email
[email protected]
Published
2003-11-00
Epub
2003-00-25
Pages
986-93
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1180504
Subset
IM
Databases
OMIM
ATP1A2, CACNA1A, EA2, FHM1, FHM2, FHM3, MGR1, MGR2, MGR3, MGR4, MGR5, MGR6, SCA6
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1086/378417 PMC Full Text View journal details
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