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PMID: 14574648 Published · ppublish English Letter Meta-Analysis

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.

American journal of human genetics ·Vol. 73 ·No. 5 ·2003-11-00 ·Pages 1208-12

Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, Evans J, Del Bosque-Plata L, Hitman G, Walker M, Levy JC, Sampson M, Bell GI, McCarthy MI, Hattersley AT, Frayling TM

Abstract

暂无摘要

MeSH Terms
Calpain/genetics Case-Control Studies Diabetes Mellitus, Type 2/genetics Genetic Linkage/genetics Genetic Predisposition to Disease/genetics Humans Polymorphism, Single Nucleotide/genetics Racial Groups/genetics Reproducibility of Results
Chemicals
Calpain calpain 10
Authors & Affiliations
20 authors, click to expand affiliations / ORCID
Weedon Michael N
Schwarz Peter E H
Horikawa Yukio
Iwasaki Naoko
Illig Thomas
Holle Rolf
Rathmann Wolfgang
Selisko Thomas
Schulze Jan
Owen Katherine R
Evans Julie
Del Bosque-Plata Laura
Hitman Graham
Walker Mark
Levy Jonathan C
Sampson Mike
Bell Graeme I
McCarthy Mark I
Hattersley Andrew T
Frayling Timothy M
References (24)
24 references, click to expand
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  7. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
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  8. The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
2003-11-00
Pages
1208-12
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1180500
Subset
IM
Grants
NIDDK NIH HHS · P30 DK020595 · United States
NIDDK NIH HHS · P60 DK020595 · United States
NIDDK NIH HHS · R01 DK047486 · United States
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