Home LiteratureArticle Details
PMID: 1457777 Published · ppublish English Journal Article Review

Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex.

Seminars in cell biology ·Vol. 3 ·No. 5 ·1992-10-00 ·Pages 343-55

Saraste J, Kuismanen E

Abstract

Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway. Localization of resident marker proteins has shown that this compartment consists of both peripheral and central elements. The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface. We propose a model which describes how mobile, endosome-like elements of the pre-Golgi compartment function in the generation of the compositional and functional boundary between the widely distributed ER and the more centrally located Golgi stacks.

MeSH Terms
Animals Biological Transport/physiology Endoplasmic Reticulum/physiology,ultrastructure Golgi Apparatus/physiology,ultrastructure Humans Intracellular Membranes/physiology,ultrastructure Microscopy, Electron Protein Processing, Post-Translational/physiology Ribosomes/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Saraste J
Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.
Kuismanen E
References (93)
93 references, click to expand
  1. Microtubules, membrane traffic, and cell organization.
    Cell. 1990 Apr 6;61(1):5-7 PMID: 2180584
  2. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic.
    Cell. 1991 Nov 1;67(3):601-16 PMID: 1682055
  3. A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules.
    Nature. 1991 Aug 1;352(6334):441-4 PMID: 1861723
  4. Intracellular aspects of the process of protein synthesis.
    Science. 1975 Aug 1;189(4200):347-58 PMID: 1096303
  5. Progress in unraveling pathways of Golgi traffic.
    Annu Rev Cell Biol. 1985;1:447-88 PMID: 3916320
  6. Dynamic behavior of endoplasmic reticulum in living cells.
    Cell. 1988 Jul 1;54(1):37-46 PMID: 3383243
  7. Protein oligomerization in the endoplasmic reticulum.
    Annu Rev Cell Biol. 1989;5:277-307 PMID: 2688707
  8. The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family.
    Cell. 1989 Jul 14;58(1):133-45 PMID: 2526682
  9. Intracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis.
    Cell. 1983 Jan;32(1):277-87 PMID: 6130851
  10. Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal.
    Nature. 1990 Jun 7;345(6275):495-502 PMID: 2161500
  11. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation.
    Cell. 1983 Aug;34(1):233-43 PMID: 6883510
  12. Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S.
    J Cell Biol. 1992 Mar;116(6):1357-67 PMID: 1541633
  13. Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus.
    Eur J Cell Biol. 1990 Dec;53(2):185-96 PMID: 1964413
  14. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin.
    Nature. 1991 Jan 17;349(6306):215-20 PMID: 1898984
  15. Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus.
    J Cell Biol. 1988 Nov;107(5):1643-53 PMID: 3182932
  16. The neuronal endomembrane system. I. Direct links between rough endoplasmic reticulum and the cis element of the Golgi apparatus.
    J Neurosci. 1985 Dec;5(12):3111-23 PMID: 3878393
  17. Degradation of proteins within the endoplasmic reticulum.
    Curr Opin Cell Biol. 1991 Aug;3(4):592-600 PMID: 1772654
  18. Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein.
    Nature. 1989 Jun 1;339(6223):397-8 PMID: 2542798
  19. Effects of Brefeldin A on the Golgi complex, endoplasmic reticulum and viral envelope glycoproteins in murine erythroleukemia cells.
    Eur J Cell Biol. 1991 Feb;54(1):38-54 PMID: 2032551
  20. Membrane flow and intercoversions among endomembranes.
    Biochim Biophys Acta. 1979 Apr 23;559(1):71-52 PMID: 375982
  21. Protein localization and membrane traffic in yeast.
    Annu Rev Cell Biol. 1985;1:115-43 PMID: 3916315
  22. The reorganization of the Golgi complex in anoxic pancreatic acinar cells.
    Pancreas. 1986;1(2):95-109 PMID: 3575304
  23. Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.
    EMBO J. 1988 Apr;7(4):913-8 PMID: 3402439
  24. Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects.
    J Biol Chem. 1987 Mar 5;262(7):3362-8 PMID: 3546306
  25. A human homologue of the yeast HDEL receptor.
    Nature. 1990 Nov 8;348(6297):162-3 PMID: 2172835
  26. The trans Golgi network: sorting at the exit site of the Golgi complex.
    Science. 1986 Oct 24;234(4775):438-43 PMID: 2945253
  27. Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface.
    Cell. 1984 Sep;38(2):535-49 PMID: 6432345
  28. Endocytosis of simian virus 40 into the endoplasmic reticulum.
    J Cell Biol. 1989 Dec;109(6 Pt 1):2721-9 PMID: 2556405
  29. A C-terminal signal prevents secretion of luminal ER proteins.
    Cell. 1987 Mar 13;48(5):899-907 PMID: 3545499
  30. Brefeldin A induces a microtubule-dependent fusion of galactosyltransferase-containing vesicles with the rough endoplasmic reticulum.
    Biol Cell. 1991;71(1-2):25-31 PMID: 1912946
  31. Recycling of proteins between the endoplasmic reticulum and Golgi complex.
    Curr Opin Cell Biol. 1991 Aug;3(4):585-91 PMID: 1663369
  32. Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect.
    J Cell Biol. 1991 Nov;115(4):971-81 PMID: 1955466
  33. Targeting and processing of glycophorins in murine erythroleukemia cells: use of brefeldin A as a perturbant of intracellular traffic.
    Proc Natl Acad Sci U S A. 1989 Sep;86(18):6992-6 PMID: 2780556
  34. Mitotic Golgi fragments in HeLa cells and their role in the reassembly pathway.
    J Cell Biol. 1989 Aug;109(2):463-74 PMID: 2503521
  35. Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.
    J Cell Biol. 1990 Dec;111(6 Pt 1):2295-306 PMID: 2277061
  36. Transport of secretory and membrane glycoproteins from the rough endoplasmic reticulum to the Golgi. A rate-limiting step in protein maturation and secretion.
    J Biol Chem. 1988 Feb 15;263(5):2107-10 PMID: 3276683
  37. Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver.
    Cell. 1984 May;37(1):195-204 PMID: 6327050
  38. Dissection of a single round of vesicular transport: sequential intermediates for intercisternal movement in the Golgi stack.
    Cell. 1989 Feb 10;56(3):357-68 PMID: 2536591
  39. Motor proteins for cytoplasmic microtubules.
    Curr Opin Cell Biol. 1992 Feb;4(1):66-73 PMID: 1532721
  40. Isolation of a functional vesicular intermediate that mediates ER to Golgi transport in yeast.
    J Cell Biol. 1990 Jul;111(1):45-53 PMID: 2195039
  41. The biogenesis of lysosomes.
    Annu Rev Cell Biol. 1989;5:483-525 PMID: 2557062
  42. Three-dimensional structure of endosomes in BHK-21 cells.
    Proc Natl Acad Sci U S A. 1986 May;83(9):2899-903 PMID: 3458249
  43. Recycling of proteins from the Golgi compartment to the ER in yeast.
    J Cell Biol. 1990 Aug;111(2):369-77 PMID: 2199456
  44. The microtubule-dependent formation of a tubulovesicular network with characteristics of the ER from cultured cell extracts.
    Cell. 1988 Jul 1;54(1):27-35 PMID: 3289756
  45. Biosynthetic protein transport in the secretory pathway.
    Curr Opin Cell Biol. 1989 Aug;1(4):648-54 PMID: 2516740
  46. The Golgi complex: in vitro veritas?
    Cell. 1992 Mar 6;68(5):829-40 PMID: 1547485
  47. Compartmental organization of the Golgi stack.
    Cell. 1985 Aug;42(1):13-21 PMID: 3926324
  48. The golgi apparatus: two organelles in tandem.
    Science. 1981 Sep 11;213(4513):1212-9 PMID: 7268428
  49. The cell biology of antigen processing and presentation.
    Annu Rev Immunol. 1991;9:707-44 PMID: 1910692
  50. Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum.
    Cell. 1992 Jan 24;68(2):353-64 PMID: 1310258
  51. Sorting and traffic in the central vacuolar system.
    Cell. 1989 Jun 2;57(5):703-6 PMID: 2655928
  52. Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport.
    FASEB J. 1990 Mar;4(5):1460-8 PMID: 2407590
  53. Intracellular vesicles involved in the transport of Semliki Forest virus membrane proteins to the cell surface.
    EMBO J. 1983;2(11):2001-6 PMID: 6641709
  54. Distribution of the intermediate elements operating in ER to Golgi transport.
    J Cell Sci. 1991 Nov;100 ( Pt 3):415-30 PMID: 1808196
  55. Characterization of a 58 kDa cis-Golgi protein in pancreatic exocrine cells.
    J Cell Sci. 1992 Oct;103 ( Pt 2):321-33 PMID: 1478936
  56. Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles.
    J Biol Chem. 1989 Oct 15;264(29):17494-501 PMID: 2793869
  57. Cell biology. Tracking an elusive receptor.
    Nature. 1990 Jun 7;345(6275):480-1 PMID: 2161498
  58. Immunoelectron microscopic studies of the intracellular transport of the membrane glycoprotein (G) of vesicular stomatitis virus in infected Chinese hamster ovary cells.
    J Cell Biol. 1983 Dec;97(6):1777-87 PMID: 6315743
  59. Microtubules and the organization of the Golgi complex.
    Exp Cell Res. 1985 Jul;159(1):1-16 PMID: 3896822
  60. Regulation of protein export from the endoplasmic reticulum.
    Annu Rev Cell Biol. 1988;4:257-88 PMID: 3058161
  61. Antibodies to rat pancreas Golgi subfractions: identification of a 58-kD cis-Golgi protein.
    J Cell Biol. 1987 Nov;105(5):2021-9 PMID: 3316245
  62. Protein transport. Signals and salvage sequences.
    Nature. 1987 May 7-13;327(6117):17-8 PMID: 3574462
  63. Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin.
    Cell. 1991 Feb 8;64(3):649-65 PMID: 1840503
  64. Molecular dissection of the secretory pathway.
    Nature. 1992 Jan 30;355(6359):409-15 PMID: 1734280
  65. Brefeldin A: insights into the control of membrane traffic and organelle structure.
    J Cell Biol. 1992 Mar;116(5):1071-80 PMID: 1740466
  66. The rate of bulk flow from the endoplasmic reticulum to the cell surface.
    Cell. 1987 Jul 17;50(2):289-300 PMID: 3594573
  67. Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.
    J Cell Biol. 1985 Sep;101(3):949-64 PMID: 2863275
  68. Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum.
    J Biol Chem. 1989 Jul 25;264(21):12590-5 PMID: 2545712
  69. Salvage receptors: two of a kind?
    Cell. 1990 Jul 13;62(1):1-2 PMID: 2163762
  70. Isolation of a vesicular intermediate in the cell-free transfer of membrane from transitional elements of the endoplasmic reticulum to Golgi apparatus cisternae of rat liver.
    J Biol Chem. 1988 Nov 25;263(33):17738-48 PMID: 3182869
  71. Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59.
    J Cell Biol. 1988 May;106(5):1475-87 PMID: 2836431
  72. Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.
    Cell. 1990 Mar 9;60(5):821-36 PMID: 2178778
  73. Functions of microtubule-based motors.
    Annu Rev Physiol. 1991;53:629-52 PMID: 2042975
  74. Transient activity of Golgi-like membranes as donors of vesicular stomatitis viral glycoprotein in vitro.
    J Cell Biol. 1981 Sep;90(3):697-704 PMID: 6270159
  75. Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes.
    Cell. 1991 Nov 1;67(3):591-600 PMID: 1657400
  76. Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae.
    Cell. 1991 Mar 22;64(6):1183-95 PMID: 2004424
  77. Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex.
    J Cell Biol. 1967 Aug;34(2):577-96 PMID: 6035647
  78. Replication of coronavirus MHV-A59 in sac- cells: determination of the first site of budding of progeny virions.
    Eur J Cell Biol. 1984 Mar;33(2):281-93 PMID: 6325194
  79. Low temperature-induced transport blocks as tools to manipulate membrane traffic.
    Methods Cell Biol. 1989;32:257-74 PMID: 2691852
  80. The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi.
    J Cell Biol. 1991 Apr;113(1):45-54 PMID: 2007626
  81. Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments.
    Cell. 1985 Mar;40(3):635-43 PMID: 3882239
  82. From G minor to G major.
    Curr Biol. 1992 Mar;2(3):157-60 PMID: 15335994
  83. Control of protein exit from the endoplasmic reticulum.
    Annu Rev Cell Biol. 1989;5:1-23 PMID: 2688704
  84. A vesicular intermediate in the transport of hepatoma secretory proteins from the rough endoplasmic reticulum to the Golgi complex.
    J Cell Biol. 1987 Feb;104(2):221-30 PMID: 3027103
  85. Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.
    J Cell Biol. 1989 Jul;109(1):61-72 PMID: 2745557
  86. Involvement of beta-COP in membrane traffic through the Golgi complex.
    Trends Cell Biol. 1991 Jul;1(1):14-9 PMID: 14731804
  87. The mannose-6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae.
    Cell. 1984 Feb;36(2):295-307 PMID: 6319015
  88. Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae.
    J Cell Biol. 1982 Apr;93(1):223-9 PMID: 6121819
  89. The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.
    J Cell Biol. 1981 Dec;91(3 Pt 2):77s-103s PMID: 7033246
  90. Passage of viral membrane proteins through the Golgi complex.
    J Mol Biol. 1981 Nov 15;152(4):663-98 PMID: 7038131
  91. Immunocytochemical localization of BiP to the rough endoplasmic reticulum: evidence for protein sorting by selective retention.
    J Histochem Cytochem. 1989 Dec;37(12):1817-23 PMID: 2685110
  92. Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation.
    Cell. 1985 Nov;43(1):287-95 PMID: 3000603
  93. The Golgi apparatus: insights from lipid biochemistry.
    Biochem Soc Trans. 1990 Jun;18(3):361-6 PMID: 2197129
Article Info
Journal
Seminars in cell biology
Abbr.
Semin Cell Biol
ISSN
1043-4682
DOI
10.1016/1043-4682(92)90020-v
Published
1992-10-00
Pages
343-55
Language
English
Region
England
NLM ID
9007587
PMCID
PMC7128811
Subset
IM
External Links
PubMed source DOI: 10.1016/1043-4682(92)90020-v PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2