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PMID: 1460430 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.

The Journal of experimental medicine ·Vol. 176 ·No. 6 ·1992-12-01 ·Pages 1757-61

Bluestone JA, Jameson S, Miller S, Dick R

Abstract

Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha 1 and alpha 2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity.

MeSH Terms
Amino Acid Sequence Animals Antibodies, Monoclonal Binding Sites Cell Transformation, Viral Histocompatibility Antigens Class I/chemistry,metabolism Humans Lymphoma Major Histocompatibility Complex Molecular Sequence Data Mutagenesis, Site-Directed Ovalbumin/chemistry,immunology Peptides/chemical synthesis,chemistry Protein Conformation Rauscher Virus/genetics Tumor Cells, Cultured
Chemicals
Antibodies, Monoclonal Histocompatibility Antigens Class I Peptides Ovalbumin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bluestone J A
Department of Pathology, Ben May Institute, University of Chicago, Illinois 60637.
Jameson S
Miller S
Dick R
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30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.176.6.1757
Published
1992-12-01
Pages
1757-61
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2119441
Subset
IM
Grants
NIAID NIH HHS · P01 AI-29531 · United States
NCI NIH HHS · P30 CA-14599 · United States
External Links
PubMed source DOI: 10.1084/jem.176.6.1757 PMC Full Text View journal details
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