Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells.

The Journal of cell biology ·Vol. 163 ·No. 3 ·2003-11-10 ·Pages 437-40

Peifer M, Yap AS

Abstract

Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking (Chen et al., 2003; Davis et al., 2003; Xiao et al., 2003).

MeSH Terms

Adherens Junctions/metabolism Animals Cadherins/metabolism Catenins Cell Adhesion/physiology Cell Adhesion Molecules/metabolism Cell Membrane/metabolism Humans Mammals Phosphoproteins/metabolism Protein Transport/physiology Signal Transduction/physiology

Chemicals

Cadherins Catenins Cell Adhesion Molecules Phosphoproteins delta catenin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Peifer Mark

Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. [email protected]

Yap Alpha S

References (21)

21 references, click to expand

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The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn.
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Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation.
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The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis.
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A core function for p120-catenin in cadherin turnover.
J Cell Biol. 2003 Nov 10;163(3):525-34 PMID: 14610055
Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells.
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Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells.
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p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions.
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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.200310090

[email protected]

Published

2003-11-10

Pages

437-40

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2173635

Subset

Corrections

CommentOn

PMID: 14610055

CommentOn

PMID: 14610056

CommentOn

PMID: 14610057

External Links

PubMed source DOI: 10.1083/jcb.200310090 PMC Full Text View journal details

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Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells.

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